Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Figure 6

Coronal CT scanning of the dogs number 1 (A) and number 2 (B) one week postoperatively. (a) Five implants in the basal cisterns (thick arrow), no clinical signs of intolerance observed. Craniotomy site is indicated by thin arrow. (b) Scanning indicates a too rostral positioning of the implants, and five implants had formed pile-like formation protruding into the parenchyma of the frontal lobe (thick arrow). Craniotomy site is indicated by thin arrow.

(a)

(b)