Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Table 1

Allocation of treatment groups and schedule of the pig study.

Group	Procedure	Parenchyma implant	Animals per group	Animal IDs
Sham	Sham operation	No implant	3	22A, 22B, and 23C
Placebo	Placebo implant 25 mg glucose × 1	Placebo implant	3	22C, 23A, and 23F
Active	Nimodipine implant 5 mg × 1	Placebo implant	3	23B, 23D, and 23E
Samples	Day 1	Day 4	Day 5^1	Day 7
Plasma (ear vein)			x	x
Plasma (vena jugularis)	x	x	x	x
Cerebrospinal fluid			x	x
CT	x			x^2

Day 6 on animals 22A, 22B, and 22C.
Only animals 23A and 23D underwent CT-imaging.