Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model

Table 3

Clinical signs of the dogs during the 21-day recovery period.

Group	Dog number	Epileptic seizure	Other/notice
Active 1	1	No	—
	2	Yes	Epileptiformic seizure on day 4. Treated with phenobarbital medication 2.5 mg/kg twice a day on days 4–12. The medication was reduced to 2.5 mg/kg once a day on day 13 and ended on day 20.
	3	Yes	Epileptiformic seizure 6 hours postoperatively. Epileptiformic seizures were refractory to phenobarbital medication. The animal had to be euthanized on day 3 according to the protocol. It was not replaced.
Active 2	4	No	24 h postoperatively, conjunctivitis.
	5	No	24 h postoperatively, vomiting.
	6	No	24 h postoperatively, conjunctivitis.
Sham	7	No	—
	8	No	24 h postoperatively, conjunctivitis.
	9	No	—