Intracranial Biodegradable Silica-Based Nimodipine Drug Release Implant for Treating Vasospasm in Subarachnoid Hemorrhage in an Experimental Healthy Pig and Dog Model
Table 4
Summary of histopathological findings and severity in pigs and dogs in each group. The number of affected animals in each group is shown. Severity score indicates the recorded minimum and maximum severity in each group. Only one score is shown if all animals had same severity or only one animal was affected. in each group.
Lesion
Pigs
Dogs
Sham
Placebo
Active
Sham
Active 1*
Active 2
Infiltration of mononuclear cells (meninges)
1
3
3
3
2
3
Severity score,
++++
++/+++
+/++++
++++
++++
+++/++++
Infiltration of granulocytes (meninges)
1
1
1
3
2
3
Severity score, min/max
++++
+
++
+/+++
+++
+/++
Multinucleated giant cells and foreign material (meninges)
0
0
0
0
2
1
Severity score, min/max
—
—
—
—
++
++
Fibrosis (meninges)
1
3
1
3
2
3
Severity score, min/max
++
+
++
++/+++
+++/++++
++/++++
Vascular regeneration (meninges)
0
2
0
3
1
3
Severity score, min/max
—
+++
—
++
++
++
Hemorrhage +/− hemosiderophages (meninges)
1
2
1
2
1
3
Severity score, min/max
+
+/+++
++++
++
++
++
Perivascular cuffing (parenchyma)
0
0
1
3
2
3
Severity score, min/max
—
—
+
+/+++
++
+/++
In this group, . Animal number 3 was excluded due to preterminal sacrifice. +: minimal, ++: slight, +++: moderate, ++++: marked, and —: not present.
