Evaluation of MicroRNAs Regulating Anoikis Pathways and Its Therapeutic Potential

Table 1

MiRNAs known to play roles in (a) promoting anoikis and (b) inhibiting anoikis.

(a)

MiRNA	Cancer type	Target	Signalling pathway	Reference
miR-204	Gastric	SIRT1	SIRT1-LKB1, PI3K/AKT	[26, 29]
miR-26a	Liver	ITGA5	PI3K/AKT	[30–32]
miR-31	Breast	RhoA, ITGA5	PI3K/AKT	[34]
miR-451	Glioma; Nonsmall cell lung cancer	CAB39; Rab14	PI3K/AKT	[38, 39]; [42]
miR-200b	Breast	Pin1	PI3K/AKT	[43]
miR-200c	Breast	TrkB	PI3K/AKT	[44–46]
miR-424-5p	Liver	CAT/CTNNBIP1	Wnt	[47]
miR-494	Pancreatic	FOXM1	Wnt	[48]

(b)

MiRNA	Cancer type	Target	Signalling pathway	Reference
miR-125b	—	p53	MAP/ERK	[49]
miR-181a	Breast	Bim	—	[50]
miR-145	Esophageal	—	—	[51]
miR-421	Pancreatic	Smad4	TGF-β/SMAD	[52]
miR-146a	Leukemia	Smad4	TGF-β/SMAD	[53–56]
miR-483-3p	Pancreatic	Smad4	TGF-β/SMAD	[57, 58]
miR-199a	Gastric	Smad4	TGF-β/SMAD	[59]