Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme

Table 2

Positive and negative regulators on DCs. TNF: tumor necrosis factor, ICOS: inducible costimulator, TNFRSF4: tumor necrosis factor receptor superfamily-member 4, TNFSF14: tumor necrosis factor ligand superfamily-member 14, GITR: glucocorticoid-induced tumor necrosis factor receptor, PD-L1: programmed death 1 ligand, A20: zinc finger protein A20, SOCS1: the suppressor of cytokine signaling 1, and DIgR2: DC-derived immunoglobulin receptor 2.

Positive regulators		Negative regulators
B7/CD28 family	TNF/TNF receptor family
CD80 (B7-1) [25]; CD86 (B7-2) [25]; B7-H2 (ICOS ligand) [26]; B7-H3 [27]	CD27 [30]; TNFRSF4 [31]; CD137 (4-1 BB) [30]; TNFSF14 [29]; GITR [30]	PD-L1 (B7-H1) [22]; PD-L2 (B7-DC) [40]; B7-H4 [28]; A20 [42]; SOCS1 [43]; DIgR2 [44]; Notch ligands [44]