Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

Table 2

Mean serum levels and range are shown for cytokines, chemokines, and growth factors (in pg/mL) at inclusion and at the end of intake of study product for the Agaricus ( = 16) and the placebo group ( = 17). The statistical relationship of the differences of the means of the two groups is shown in the column “A/P.”

	Agaricus			Placebo			A/P
	Start; Mean	End; Mean	Difference	Start; Mean	End; Mean	Difference	value
IL-1ra	53.21	84.51	31.30	94.79	69.46	−25.33	= 0.02
(Range)	(7.21–125.52)	(21.9–268.37)		(21.69–268.37)	(6.10–167.65)
IL-4	1.57	2.01	0.44	1.82	1.84	0.02	n.s.
(Range)	(0.39–3.31)	(0.75–4.17)		(0.54–5.27)	(0.42–4.97)
IL-5	1.66	2.89	1.23	2.75	2.21	−0.54	= 0.05
(Range)	(0.02–4.89)	(0.19–9.37)		(0.36–8.29)	(0.43–5.60)
IL-6	4.65	7.71	3.07	9.55	10.39	0.84	n.s.
(Range)	(0.03–11.32)	(0.88–18.40)		(2.29–28.67)	(2.60–32.82)
IL-7	4.77	6.91	2.12	6.52	6.12	−0.40	= 0.05
(Range)	(1.37–8.30)	(2.61–14.06)		(2.09–10.41)	(2.34–13.18)
IL-8	12.59	15.14	2.54	13.49	15.41	1.91	n.s.
(Range)	(4.13–27.89)	(6.82–48.34)		(5.74–26.00)	(6.10–38.79)
IL-13	5.58	5.98	0.40	6.78	9.27	2.49	n.s.
(Range)	(0.87–20.94)	(0.02–13.45)		(0.87–12.48)	(0.87–39.33)
Eotaxine	93.11	105.31	12.20	162.33	112.39	−49.94	n.s.
(Range)	(0.11–247.02)	(16.59–229.25)		(23.02–600.07)	(11.00–368.73)
G-CSF	19.06	21.94	2.89	22.34	19.54	−2.79	n.s.
(Range)	(5.60–41.66)	(9.63–38.64)		(9.99–34.41)	(7.82–33.92)
gammaIFN	55.41	75.36	19.96	65.69	62.06	−3.62	n.s.
(Range)	(3.24–179.72)	(17.25–161.35)		(13.32–205.88)	(1.64–156.12)
IP10	3198.89	3647.61	448.71	3230.03	3677.51	447.40	n.s.
(Range)	(1047.70–8564.00)	(391.37–12899.26)		(562.41–9314.66)	(277.79–13636.42)
MCAF	63.73	43.46	−19.27	50.17	43.98	−6.20	n.s.
(Range)	(8.14–236.81)	(13.89–97.58)		(15.37–90.94)	(19.88–134.84)
MIPa	50.46	42.48	−7.98	62.87	46.69	−16.16	n.s.
(Range)	(28.88–71.61)	(21.56–84.55)		(17.66–238.61)	(21.73–79.61)
PDGF	426.31	450.75	24.44	454.23	158.52	−295.71	n.s.
(Range)	(75.90–1327.12)	(19.06–3841.38)		(45.84–1632.87)	(20.99–309.16)
RANTES	10217.89	7497.97	−2719.93	6496.38	4672.52	−1823.86	n.s.
	(1846.39–30848.81)	(1595.65–29043.80)		(644.32–23964.69)	(119.20–10435.40)
TNF alpha	6.29	12.35	6.07	10.52	12.05	1.53	n.s.
	(0.97–21.66)	(0.22–42.11)		(0.97–41.87)	(0.22–50.85)