Sustained Reduction of Cerebellar Activity in Experimental Epilepsy

Figure 3

(a) Representative photomicrographs (4x magnification) showing COX activity in the deep cerebellar nuclei of a sham and a fully amygdala kindled rat. Note the overall reduction in COX activity in the kindled rat, suggesting a general decrease in neuronal activity. Coronal sections were taken at bregma level −11.30. 4V: fourth ventricle; DN: dentate nucleus; IN: interpositus nucleus; FN: fastigial nucleus. (b) Corrected optical density of COX activity in the deep cerebellar nuclei. The optical density was corrected for background staining by subtracting the optical density of the adjacent white matter, leading to a negative value. Data represent mean ± SEM of 101 sections from 6 sham animals and 92 sections from 6 kindled animals. .

(a)

(b)