Research Article
Insulin Resistance-Associated Interhemispheric Functional Connectivity Alterations in T2DM: A Resting-State fMRI Study
Table 1
Demographic and clinical characteristics.
| | Items |
T2DM patients
() |
Healthy controls
() | value | | Mean | SD | Mean | SD |
| | Age, years | 59.5 | 8.2 | 56.2 | 7.1 | 0.106 | | Gender, male : female | 16 : 14 | | 13 : 15 | | 0.599 | | Education levels, years | 9.8 | 3.8 | 10.6 | 3.2 | 0.299 | | Diabetes duration, years | 10.0 | 5.8 | — | — | — | | History of smoking, yes : no | 4 : 26 | | 6 : 22 | | 0.415 | | BMI, kg/m2 | 25.3 | 2.7 | 24.7 | 2.4 | 0.329 | | Systolic BP, mmHg | 129.0 | 19.7 | 129.5 | 15.0 | 0.895 | | Diastolic BP, mmHg | 78.4 | 9.4 | 80.5 | 7.4 | 0.342 | | HbA1c, % (mmol/mol) | 8.0 (64) | 1.6 (17.5) | 5.8 (40) | 0.6 (6.6) | <0.00 | | Fasting glucose, mmol/L | 8.3 | 2.4 | 6.0 | 0.9 | <0.00 | | Fasting serum insulin, U/L | 11.0 | 4.0 | 5.6 | 2.1 | <0.00 | | HOMA-IR | 3.8 | 1.1 | 1.5 | 0.5 | <0.00 | | Triglyceride, mmol/L | 1.5 | 0.7 | 1.4 | 0.7 | 0.814 | | Total cholesterol, mmol/L | 5.5 | 1.2 | 5.7 | 0.8 |
0.576 | | LDL-C, mmol/L | 3.4 | 0.8 | 3.4 | 0.5 | 0.996 | | HDL-C, mmol/L | 1.4 | 0.3 | 1.4 | 0.3 | 0.987 | | Intima-media thickness, mm | 1.0 | 0.2 | 0.9 | 0.2 | 0.059 | | Blood pressure lowering medications, yes : no | 10 : 20 | | 8 : 20 | | 0.695 | | Cholesterol lowering medications, yes : no | 9 : 21 | | 3 : 25 | | 0.07 |
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HOMA2-IR, homeostasis model assessment-insulin resistance; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.
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