Activation of Cell Surface Bound 20S Proteasome Inhibits Vascular Cell Growth and Arteriogenesis
Decreased proliferation, number of collateral vessels, and total collateral conductance after in vivo injection of CTA 157-2 as compared to injection of control IgM: (a) BrdU incorporating nuclei (green/FITC) in relation to total nuclei (blue staining/DAPI) in collateral vessels of CTA 157-2 treated and control animals, (b) postmortem angiography of animal treated with CTA157-2, and (c) postmortem angiography of control animal (black arrows: collateral vessels). (d) Quantitative comparison of proliferation index (scale bar represents 100 μm; 6 animals per group, ). (e) Quantification of visible collateral vessels using stereoscopic analysis (6 animals per group; ). (f) Total collateral conductance in animals treated with CTA 157-2 as compared to control (3 animals per group; ).
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