Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients

Table 4

Multivariate analysis of overall survival.

Variables	Overall survival
	HR (95% CI)	value	Prognostic impact
All 67 patients
FLT3 ITD mutation (compared with wild type)	2.798 (1.041–7.517)	0.041	Poor
DNMT3A mutation (compared with wild type)
Nonsynonymous variations	1.229 (0.391–3.864)	0.724	NS^*
Deleterious mutations	2.285 (0.459–11.374)	0.313	NS^*
R882 mutation	2.285 (0.459–11.374)	0.313	NS^*
Increasing age	1.023 (0.991–1.055)	0.157	NS
Increrasing BM blasts	1.018 (0.986–1.051)	0.285	NS
SCT performed (compared to not performed)	0.118 (0.035–0.399)	0.001	Good

Note: values were adjusted with FLT3 ITD mutation status, age, BM blast percentage, and stem cell transplantation performance status (in all 67 patients^*).
FLT3: fms-related tyrosine kinase 3; ITD: internal tandem duplications; DNMT3A: DNA methyltransferase 3A; R: arginine; BM: bone marrow; SCT: stem cell transplantation; HR: hazard ratio; CI: confidence interval; NS: not significant.