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BioMed Research International
Volume 2015, Article ID 724715, 10 pages
http://dx.doi.org/10.1155/2015/724715
Research Article

Detecting Key Genes Regulated by miRNAs in Dysfunctional Crosstalk Pathway of Myasthenia Gravis

1Department of Neurology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China
2Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China
3College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China

Received 11 August 2014; Accepted 10 December 2014

Academic Editor: Dongchun Liang

Copyright © 2015 Yuze Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: MiRNAs and mRNAs differentially expressed in MG Table S1 lists the miRNAs and mRNAs differentially expressed in MG. A total of 46 differentially expressed miRNAs were identified, including 21 upregulated miRNAs and 25 downregulated miRNAs. A total of 1135 differentially expressed mRNAs were obtained, including 551 upregulated mRNAs and 584 downregulated mRNAs.

Table S2: The predicted targets of differentially expressed miRNAs

Table S2 lists the predicted targets of differentially expressed miRNAs. A total of 46 differentially expressed miRNAs, 9567 predicted targets, 34963 miRNA-target regulations were obtained.

Table S3: Pathways enriched in differentially expressed mRNAs and predicted target genes of differentially expressed miRNAs

Table S3 presents significant pathways enriched by differentially expressed mRNAs and predicted genes of differentially expressed miRNAs. The up- and down-regulated mRNAs were significantly enriched in 13 pathways (define as P1) and 8 pathways (define as P2), respectively. The predicted targets of up- and down-regulated miRNAs were significantly enriched in 64 pathways (define as P3) and 68 pathways (define as P4), respectively.

  1. Supplementary Material