An Activity of Thioacyl Derivatives of 4-Aminoquinolinium Salts towards Biofilm Producing and Planktonic Forms of Coagulase-Negative Staphylococci
Table 1
Phenotypic and genotypic characterization data from 41 CoNS strains.
Strain number
Bacterial species
Biofilm status
MP ( ± SD)
CRA plate
Presence of icaA/icaD
1
S. saprophyticus
Biofilm-negative
0.07 ± 0.01
r
ND
2
S. klosii
Biofilm-positive
0.44 ± 0.08
b
ND
4
S. cohnii subsp. urealyticum
Biofilm-negative
0.11 ± 0.01
r
ND
5
S. haemolyticus
Biofilm-negative
0.08 ± 0.02
r
ND
14
S. cohnii subsp. cohnii
Biofilm-negative
0.10 ± 0.04
g
ND
24
S. epidermidis
Biofilm-positive
0.48 ± 0.06
r
+/−
25
S. epidermidis
Biofilm-positive
0.44 ± 0.10
r
+/−
26
S. epidermidis
Biofilm-positive
0.61 ± 0.03
r
+/+
27
S. epidermidis
Biofilm-negative
0.07 ± 0.02
r
−/+
28
S. epidermidis
Biofilm-negative
0.08 ± 0.01
r
−/−
32
S. warneri
Biofilm-negative
0.06 ± 0.01
r
ND
33
S. epidermidis
Biofilm-positive
0.19 ± 0.01
r
+/−
53
S. epidermidis
Biofilm-negative
0.13 ± 0.01
r
+/+
62
S. cohnii subsp. cohnii
Biofilm-negative
0.07 ± 0.02
g
ND
64
S. epidermidis
Biofilm-negative
0.08 ± 0.02
r
−/−
65
S. epidermidis
Biofilm-positive
0.27 ± 0.08
r
−/−
76
S. epidermidis
Biofilm-positive
0.47 ± 0.05
r
+/−
78
S. epidermidis
Biofilm-positive
0.53 ± 0.10
r
+/−
84
S. epidermidis
Biofilm-negative
0.09 ± 0.02
r
−/−
90
S. epidermidis
Biofilm-negative
0.07 ± 0.01
g
−/−
91
S. epidermidis
Biofilm-positive
0.45 ± 0.04
b
+/+
93
S. haemolyticus
Biofilm-negative
0.05 ± 0.00
r
ND
95
S. epidermidis
Biofilm-negative
0.10 ± 0.05
r
−/−
96
S. haemolyticus
Biofilm-negative
0.11 ± 0.02
r
ND
97
S. epidermidis
Biofilm-positive
0.46 ± 0.01
r
+/+
99
S. epidermidis
Biofilm-positive
0.55 ± 0.05
r
+/+
101
S. haemolyticus
Biofilm-negative
0.06 ± 0.01
r
ND
102
S. epidermidis
Biofilm-negative
0.06 ± 0.00
r
−/+
103
S. capitis subsp. capitis
Biofilm-negative
0.14 ± 0.03
r
ND
105
S. haemolyticus
Biofilm-negative
0.10 ± 0.03
r
ND
107
S. epidermidis
Biofilm-negative
0.07 ± 0.02
r
−/−
125
S. warneri
Biofilm-negative
0.08 ± 0.03
r
ND
139
S. warneri
Biofilm-negative
0.10 ± 0.04
r
ND
12228
S. epidermidis ATCC 12228
Biofilm-negative
0.11 ± 0.02
r
−/−
35984
S. epidermidis ATCC 35984
Biofilm-positive
0.56 ± 0.11
b
+/+
15305
S. saprophyticus ATCC 15305
Biofilm-negative
0.09 ± 0.03
r
ND
27844
S. hominis ATCC 27844
Biofilm-negative
0.06 ± 0.01
r
ND
29970
S. haemolyticus ATCC 29970
Biofilm-negative
0.08 ± 0.03
r
ND
35661
S. capitis subsp. capitis ATCC 35661
Biofilm-negative
0.08 ± 0.01
r
ND
49454
S. warneri ATCC 49454
Biofilm-negative
0.08 ± 0.02
r
ND
49576
S. lugdunensis ATCC 49576
Biofilm-negative
0.06 ± 0.01
r
ND
CRA: type of growth on Congo Red Agar medium, r: red colonies, b: black colonies, and g: grey colonies; icaA/D: (+) presence of the gene, (−): absence of the gene, and ND: not detection. Correlation between biofilm status and MP test ; CRA plate test (); ica status (). Results were considered significant when ; Mann-Whitney nonparametric test; 2Rang Spearman test.