β-Catenin-Dependent Signaling Pathway Contributes to Renal Fibrosis in Hypertensive Rats

Figure 6

Protein levels of β-catenin-dependent gene products in 2K1C rats treated with lisinopril. Western blot analysis of cyclin D1, c-myc, and bcl-2 in the unclipped kidney from 2K1C rats treated or not treated with lisinopril was done. The protein levels of target of Wnt signaling cyclin D1, c-myc, and bcl-2 were increased in unclipped kidney. Lisinopril reverses this effect on the protein levels in all of them. The level of protein was normalized to β-actin levels and the ratio was expressed as relative units normalized to sham rats. Numbers (1, 2, and 3) in the Western blot indicate an individual animal sample in a given group. The bars represent the mean ± SEM (). .