Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

Figure 3

TM-1 administered 3 or 4 h after injury reduced TBI-induced lung AQP1 protein expression levels measured 8 and 24 h after TBI. The AQP1 protein level showed a marked decrease following TM-1 administration 3 or 4 h after injury (10 mg/kg), respectively. Rats were sacrificed 8 or 24 h after TBI. Data are expressed as mean ± SD (/group). compared with the sham-operated group; compared with the untreated groups; , comparison between mRNA expression following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 8 and 24 h after TBI; , comparison between protein levels following TM-1 administration (10 mg/kg) 3 and 4 h after injury in the rats sacrificed 24 h after TBI.