Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

Figure 6

TM-1 administered 3 or 4 h after injury reduced alveolar swelling with infiltration of inflammatory cells 8 and 24 h after TBI by H&E staining. The vehicle-treated sham-operated group showed a normal alveolar morphology. Alveolar swelling and infiltration of inflammatory cells increased 8 and 24 h in vehicle-treated TBI rats. Alveolar swelling and infiltration of inflammatory cells decreased following TM-1 administration 3 and 4 h after injury. Rats were sacrificed 8 or 24 h after TBI. Bar = 25 μm.