Serum miR-224 Reflects Stage of Hepatocellular Carcinoma and Predicts Survival

Table 2

Univariate and multivariate Cox regression analyses of parameters associated with overall survival of all HCC patients.

Parameters	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Gender (male versus female)	1.659 (0.66, 4.172)	0.282
HBV (no versus yes)	0.767 (0.375, 1.567)	0.466
Cirrhosis (no versus yes)	1.268 (0.506, 3.181)	0.613
AFP (<200 versus >200 ng/mL)	2.397 (1.339, 4.289)	0.003	1.998 (1.085, 3.681)	0.026
Child-Pugh (A versus B)	2.04 (1.041, 3.996)	0.038	/	/
BCLC (B versus C)	4.083 (2.228, 7.482)	0.000	2.865 (1.500, 5.472)	0.001
Local therapy	0.235 (0.084, 0.654)	0.006	0.170 (0.065, 0.444)	0.000
Sorafenib	1.423 (0.791, 2.562)	0.239
Serum miR-224 (low versus high)	2.188 (1.264, 3.786)	0.005	2.085 (1.142, 3.807)	0.017