Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 735689, 6 pages
http://dx.doi.org/10.1155/2015/735689
Research Article

Discover the Molecular Biomarker Associated with Cell Death and Extracellular Matrix Module in Ovarian Cancer

Department of Obstetrics and Gynecology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 40042, China

Received 5 December 2014; Revised 10 February 2015; Accepted 15 February 2015

Academic Editor: Guocai Zhong

Copyright © 2015 Qiang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

High throughput technologies have provided many new research methods for ovarian cancer investigation. In tradition, in order to find the underlying functional mechanisms of the survival-associated genes, gene sets enrichment analysis (GSEA) is always regarded as the important choice. However, GSEA produces too many candidate genes and cannot discover the signaling transduction cascades. In this work, we have used a network-based strategy to optimize the discovery of biomarkers using multifactorial data, including patient expression, clinical survival, and protein-protein interaction (PPI) data. The biomarkers discovered by this strategy belong to the network-based biomarker, which is apt to reveal the underlying functional mechanisms of the biomarker. In this work, over 400 expression arrays in ovarian cancer have been analyzed: the results showed that cell death and extracellular module are the main themes related to ovarian cancer progression.