Circulating miR-765 and miR-149: Potential Noninvasive Diagnostic Biomarkers for Geriatric Coronary Artery Disease Patients
Table 1
Clinical characteristics of the study subjects.
Characteristics
Controls ( = 20)
Stable CAD ( = 37)
Unstable CAD ( = 32)
Age (years)
71.7 ± 5.2
72.97 ± 4.28
72.03 ± 4.36
0.335
0.829
0.370
Male/female
10/10
25/12
18/14
0.257
0.777
0.333
BMI (kg/m2)
22.29 ± 1.49
23.08 ± 3.03
24.38 ± 3.46
0.334
0.015
0.072
Smoker (%)
55
64.8
75
0.571
0.224
0.362
Hypertension (%)
50
70.2
78.1
0.158
0.067
0.585
Dyslipidemia (%)
30
51.3
50
0.165
0.249
0.911
DM (%)
15%
24.3%
34.3
0.510
0.200
0.359
FBS
4.79 ± 0.43
5.04 ± 1.13
5.54 ± 1.04
0.642
0.026
0.098
SBP (mmHg)
133.05 ± 7.30
141.4 ± 16.17
137.8 ± 18.12
0.137
0.538
0.606
DBP (mmHg)
77.8 ± 4.13
78.48 ± 7.68
79.71 ± 6.80
0.734
0.332
0.450
TG (mmol/L)
1.42 ± 0.78
1.67 ± 0.73
1.87 ± 1.03
0.305
0.072
0.336
TC (mmol/L)
4.32 ± 1.38
4.4 ± 1.1
4.51 ± 1.18
0.805
0.566
0.694
HDL (mmol/L)
1.21 ± 0.28
1.18 ± 0.37
1.21 ± 0.28
0.729
0.976
0.718
LDL (mmol/L)
2.65 ± 1.29
3.13 ± 1.26
3.25 ± 1.61
0.221
0.139
0.731
hs-CRP (mg/L)
0.7 ± 0.48
14.2 ± 3.3
16.3 ± 5.3
<0.001
<0.001
0.025*
AST
15 ± 8.75
18.7 ± 10.1
17.9 ± 9.2
0.154
0.274
0.723
ALT
16.6 ± 8.99
18.4 ± 9.5
20.8 ± 9.9
0.492
0.119
0.290
Cr
82.6 ± 17.72
84 ± 18.8
86.6 ± 18.8
0.793
0.453
0.558
cTnI
0
0.05 ± 0.02
0.06 ± 0.03
<0.001
<0.001
0.095
CK-MB
0
12.1 ± 5.1
13.8 ± 3.5
<0.001
<0.001
0.086
LDH
0
198 ± 33.1
209.4 ± 52.9
<0.001
<0.001
0.220
LVEF, (%)
67.3 ± 5.14
64.1 ± 6.2
62.6 ± 7.2
0.075
0.011
0.331
Aspirin, (%)
30
45.9%
50%
0.273
0.249
0.737
Nitrates, (%)
20
40.5
46.8
0.148
0.076
0.597
β-blocker, (%)
35
62.1
65.6
0.421
0.046
0.765
CCB, (%)
25
35.1
31.2
0.389
0.757
0.567
ACEI or ARB, (%)
30
35.1
37.5
0.772
0.766
0.211
Statin, (%)
35
54.1
43.7
0.266
0.575
0.393
Diuretic, (%)
15
27.2
21.8
0.346
0.722
0.620
PCI, (%)
0
21.6
28.1
≠
≠
0.532
Data reported as mean ± SD. BMI, body mass index; DM, diabetes mellitus; FBS, fasting blood sugar; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, total glyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; hs-CRP, high sensitivity-C-reactive protein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; Cr, creatinine; cTnI, cardiac troponin I; CK-MB, creatine Kinase-MB; LDH, lactate dehydrogenase; LVEF, left ventricular ejection fraction; CCB, calcium channel blocker; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; and PCI, percutaneous coronary intervention. All values are represented as comparisons between stable CAD patients and unstable CAD patients. Mann-Whitney test was performed for continuous variables and test was performed for categorical variables. value (healthy subjects versus stable CAD patients), value (healthy subjects versus unstable CAD patients), and value (stable CAD patients versus unstable CAD patients), < 0.05.
