Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts

Table 3

Effect of OS extracts on serum biochemical parameters in rats during 14-day oral acute toxicity study.

Parameter	CON	OSA	OSF	OSE
Male
Urea (mmol/L)	6.883 ± 0.25	5.533 ± 0.40	5.417 ± 0.27	6.417 ± 0.22
Creatinine (μmol/L)	43.83 ± 1.01	42.83 ± 1.35	40.33 ± 1.62	42.67 ± 1.69
Glucose (mmol/L)	10.83 ± 0.72	9.318 ± 0.74	10.61 ± 0.91	10.18 ± 0.87
Total protein	52.52 ± 0.99	51.23 ± 1.41	50.08 ± 0.99	51.52 ± 0.93
ALT (U/L)	44.58 ± 4.11	47.52 ± 3.23	33.77 ± 3.96	39.18 ± 8.87
AST (U/L)	188.2 ± 32.25	157.3 ± 12.66	108.9 ± 12.98	112.9 ± 20.97
Bilirubin (mg/dL)	0.475 ± 0.13	0.45 ± 0.08	0.45 ± 0.05	0.36 ± 0.08
Female
Urea (mmol/L)	6.633 ± 0.47	5.5 ± 0.29	6.1 ± 0.29	6.217 ± 0.38
Creatinine (μmol/L)	45.5 ± 0.81	47.83 ± 1.62	44.67 ± 0.84	44.83 ± 0.98
Glucose (mmol/L)	8.877 ± 0.59	9.093 ± 1.06	6.225 ± 0.95	9.26 ± 0.60
Total protein	58.02 ± 2.04	59.05 ± 2.72	53.1 ± 3.98	57.45 ± 2.21
ALT (U/L)	40.58 ± 2.83	45.47 ± 3.76	31.67 ± 4.05	35.15 ± 5.47
AST (U/L)	121.3 ± 12.75	153.2 ± 12.06	95.73 ± 14.29	92 ± 11.35
Bilirubin (mg/dL)	0.5 ± 0.07	0.575 ± 0.09	0.55 ± 0.09	0.5 ± 0.09

Data are expressed as mean ± standard error of the mean (SEM) and analyzed by one-way ANOVA, followed by Dunnett’s test () as compared to respective parameter value of control groups (CON: 6 males and 6 females).