The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

Figure 3

Force-pCa dependence (a) and Ca²⁺-sensitivity (b) in LV and RV of R21C^+/+ mice compared with LV and RV of WT mice. Note that the Ca²⁺ sensitivity of force was lower in RV-WT compared to LV-WT (). The Ca²⁺ sensitivity of force was also lower in the LV of R21C^+/+ mice versus LV-WT. The pCa₅₀ was larger in the RV-R21C^+/+ compared to RV of WT mice (). No differences in the force-pCa dependence were observed between the LV versus RV of R21C^+/+ mice. Number of mice and muscle strips are as in Figure 2. Error bars are SEM.

(a)

(b)