The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

Table 1

The effect of R21C mutation in TnI on steady-state force measurements in KI R21C^+/+ mice.

Parameter	LV-WT mice	RV-WT mice	LV-R21C^+/+ mice	RV-R21C^+/+ mice
	Three mice; 22 fibers	Three mice; 16 fibers	Four mice; 30 fibers	Four mice; 30 fibers
Maximal tension/cross-section (kN/m^2)	41.8 ± 0.8	41.7 ± 0.6	36.9 ± 1.2	43.5 ± 1.0
pCa50 (calcium sensitivity)	5.76 ± 0.02	5.67 ± 0.03	5.71 ± 0.01	5.73 ± 0.01
(Hill coefficient)	2.16 ± 0.14	1.90 ± 0.10	2.19 ± 0.10	2.20 ± 0.09