Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 743051, 11 pages
http://dx.doi.org/10.1155/2015/743051
Research Article

Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model

1Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah 51412, Saudi Arabia
2Department of Pharmacology & Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia
3Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia
4Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia

Received 16 September 2014; Revised 6 November 2014; Accepted 13 November 2014

Academic Editor: Wan-Liang Lu

Copyright © 2015 Hamzah M. Maswadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Jia, F. Zhu, X. Ma, Z. W. Cao, Y. X. Li, and Y. Z. Chen, “Mechanisms of drug combinations: Interaction and network perspectives,” Nature Reviews Drug Discovery, vol. 8, no. 2, pp. 111–128, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni, “Anthracyclines: molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity,” Pharmacological Reviews, vol. 56, no. 2, pp. 185–229, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Nitiss, “Targeting DNA topoisomerase II in cancer chemotherapy,” Nature Reviews Cancer, vol. 9, no. 5, pp. 338–350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Wang and S. J. Lippard, “Cellular processing of platinum anticancer drugs,” Nature Reviews Drug Discovery, vol. 4, no. 4, pp. 307–320, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Kelland, “The resurgence of platinum-based cancer chemotherapy,” Nature Reviews Cancer, vol. 7, no. 8, pp. 573–584, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Martoni, A. Bellucco, N. Canova, and F. Pannuti, “Four-year analysis of platinum and anthracycline combination for ovarian cancer,” Oncology, vol. 46, no. 2, pp. 109–116, 1989. View at Publisher · View at Google Scholar · View at Scopus
  7. O. S. Nielsen, P. Dombernowsky, H. Mouridsen et al., “Epirubicin is not superior to doxorubicin in the treatment of advanced soft tissue sarcomas. The experience of the EORTC soft tissue and bone sarcoma group,” Sarcoma, vol. 4, no. 1-2, pp. 31–35, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Tate Thigpen, M. F. Brady, H. D. Homesley et al., “Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study,” Journal of Clinical Oncology, vol. 22, no. 19, pp. 3902–3908, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Bigioni, A. Benzo, C. Irrissuto et al., “Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumour xenograft,” Cancer Chemotherapy and Pharmacology, vol. 62, no. 4, pp. 621–629, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Zhao, M. G. Wientjes, and J. L. Au, “Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses,” Clinical Cancer Research, vol. 10, no. 23, pp. 7994–8004, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Pommier, E. Leo, H. Zhang, and C. Marchand, “DNA topoisomerases and their poisoning by anticancer and antibacterial drugs,” Chemistry and Biology, vol. 17, no. 5, pp. 421–433, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, and R. Langer, “Nanocarriers as an emerging platform for cancer therapy,” Nature Nanotechnology, vol. 2, no. 12, pp. 751–760, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. E. Davis, Z. Chen, and D. M. Shin, “Nanoparticle therapeutics: an emerging treatment modality for cancer,” Nature Reviews Drug Discovery, vol. 7, no. 9, pp. 771–782, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. J. L. Markman, A. Rekechenetskiy, E. Holler, and J. Y. Ljubimova, “Nanomedicine therapeutic approaches to overcome cancer drug resistance,” Advanced Drug Delivery Reviews, vol. 65, no. 13-14, pp. 1866–1879, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Candoni, A. Michelutti, E. Simeone, D. Damiani, M. Baccarani, and R. Fanin, “Efficacy of liposomal daunorubicin and cytarabine as reinduction chemotherapy in relapsed acute lymphoblastic leukaemia despite expression of multidrug resistance-related proteins,” European Journal of Haematology, vol. 77, no. 4, pp. 293–299, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. T. M. Allen, G. A. Austin, A. Chonn, L. Lin, and K. C. Lee, “Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size,” Biochimica et Biophysica Acta (BBA)—Biomembranes, vol. 1061, no. 1, pp. 56–64, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. U. Schroeder, “Nanoparticle technology for delivery of drugs across the blood-brain barrier,” Journal of Pharmaceutical Sciences, vol. 87, no. 11, pp. 1305–1307, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Konuspayeva, B. Faye, and G. Loiseau, “The composition of camel milk: a meta-analysis of the literature data,” Journal of Food Composition and Analysis, vol. 22, no. 2, pp. 95–101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Evers, R. G. Haverkamp, S. E. Holroyd, G. B. Jameson, D. D. S. Mackenzie, and O. J. McCarthy, “Heterogeneity of milk fat globule membrane structure and composition as observed using fluorescence microscopy techniques,” International Dairy Journal, vol. 18, no. 12, pp. 1081–1089, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Gallier, D. Gragson, R. Jiménez-Flores, and D. Everett, “Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins,” Journal of Agricultural and Food Chemistry, vol. 58, no. 7, pp. 4250–4257, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Lopez, M.-N. Madec, and R. Jimenez-Flores, “Lipid rafts in the bovine milk fat globule membrane revealed by the lateral segregation of phospholipids and heterogeneous distribution of glycoproteins,” Food Chemistry, vol. 120, no. 1, pp. 22–33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Contarini and M. Povolo, “Phospholipids in milk fat: composition, biological and technological significance, and analytical strategies,” International Journal of Molecular Sciences, vol. 14, no. 2, pp. 2808–2831, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Maswadeh, S. Hatziantoniou, C. Demetzos, K. Dimas, A. Georgopoulos, and M. Rallis, “Encapsulation of Vinblastine into new liposome formulations prepared from triticum (wheat germ) lipids and its activity against human leukemic cell lines,” Anticancer Research, vol. 20, no. 6, pp. 4385–4390, 2000. View at Google Scholar · View at Scopus
  24. A. Khan, A. A. Khan, V. Dwivedi, M. G. Ahmad, S. Hakeem, and M. Owais, “Tuftsin augments antitumor efficacy of liposomized etoposide against fibrosarcoma in Swiss albino mice,” Molecular Medicine, vol. 13, no. 5-6, pp. 266–276, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Farah, “Composition and characteristics of camel milk.,” Journal of Dairy Research, vol. 60, no. 4, pp. 603–626, 1993. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. S. Gorban and O. M. Izzeldin, “Fatty acids and lipids of camel milk and colostrum,” International Journal of Food Sciences and Nutrition, vol. 52, no. 3, pp. 283–287, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. A. A. Korish, “The antidiabetic action of camel milk in experimental type 2 diabetes mellitus: an overview on the changes in incretin hormones, insulin resistance, and inflammatory cytokines,” Hormone and Metabolic Research, vol. 46, no. 6, pp. 404–411, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. R. P. Agrawal, P. Tantia, S. Jain, R. Agrawal, and V. Agrawal, “Camel milk: a possible boon for type 1 diabetic patients,” Cellular and Molecular Biology, vol. 59, no. 1, pp. 99–107, 2013. View at Google Scholar
  29. A. A. Korish and M. M. Arafah, “Camel milk ameliorates steatohepatitis, insulin resistance and lipid peroxidation in experimental non-alcoholic fatty liver disease,” BMC Complementary and Alternative Medicine, vol. 13, article 264, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. A. A. Alhaider, A. G. M. Abdel Gader, N. Almeshaal, and S. Saraswati, “Camel milk inhibits inflammatory angiogenesis via downregulation of proangiogenic and proinflammatory cytokines in mice,” APMIS, vol. 122, no. 7, pp. 599–607, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. H. M. Habib, W. H. Ibrahim, R. Schneider-Stock, and H. M. Hassan, “Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities,” Food Chemistry, vol. 141, no. 1, pp. 148–152, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. H. M. Korashy, Z. H. Maayah, A. R. Abd-Allah, A. O. S. El-Kadi, and A. A. Alhaider, “Camel milk triggers apoptotic signaling pathways in human hepatoma HepG2 and breast cancer MCF7 cell lines through transcriptional mechanism,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 593195, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. T.-L. Hwang, W.-R. Lee, S.-C. Hua, and J.-Y. Fang, “Cisplatin encapsulated in phosphatidylethanolamine liposomes enhances the in vitro cytotoxicity and in vivo intratumor drug accumulation against melanomas,” Journal of Dermatological Science, vol. 46, no. 1, pp. 11–20, 2007. View at Publisher · View at Google Scholar · View at Scopus