BioMed Research International / 2015 / Article / Tab 2

Research Article

Clinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study

Table 2

Clinicopathological changes in PKDL lesions in relation to treatment and immune response.

ParametersBefore treatmentAfter treatment

Clinical changesNodulo-papularAbsent or low papular lesion
Erythematous over whole faceOver chin only
Macular over all bodyPresent but slightly fainter

Microscopic findings

Leishmania parasite 
Positivity with density
Positive in 91% of papulonodular cases and 40% of macular cases.
Mostly extracellular, only few intracellular. (0–20/OIF)
Negative in all except one.

Cytological changesMononuclear cells (+++)Number decreased (++)
25–300/OIF, mostly clustered20–200/OIF, Scattered.
Histiocytes predominant (15–250/OIF)Many Histiocytes (10–140/OIF)
Lymphocytes: 10–40/OIFLymphocytes: 10–60/OIF
Plasma cells, epitheloid cells occasionalPlasma cells scarce
Many activated macrophages with vacuolated appearanceSome activated macrophages with vacuolation present

Immunological responseDAT—75% positiveDAT—66% positive
MIF +ve 70%, value 17–38%MIF +ve all, value 33–65%

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