Folated Synperonic-Cholesteryl Hemisuccinate Polymeric Micelles for the Targeted Delivery of Docetaxel in Melanoma

Table 3

Physicochemical properties of DTX-loaded FA-targeted PF127-Chol micelles and nontargeted ones.

Formulations	Loading efficiency (%)	Particle size (nm)	Zeta potential (mV)	PDI	Release efficiency (RE144%)
P3S25	65.39 ± 1.05	186.93 ± 17.70	−15.60	0.36 ± 0.05	64 ± 1
P12S25	99.59 ± 2.79	171.3 ± 6.42	−7.80	0.32 ± 0.07	70 ± 2
P3F25	103.18 ± 0.06	260.57 ± 62.97	−8.50	0.43 ± 0.24	40 ± 1
P12F25	52.33 ± 5.74	83.46 ± 13.30	−7.60	0.78 ± 0.21	67 ± 2
P3S40	100.04 ± 2.48	84.04 ± 6.04	−5.85	0.52 ± 0.09	78 ± 1
P12S40	100.07 ± 3.20	89.26 ± 10.63	−5.13	0.59 ± 0.05	80 ± 4
P3F40	83.45 ± 0.70	213.23 ± 6.98	−4.72	0.38 ± 0.04	50 ± 1
P12F40	72.17 ± 1.14	140.80 ± 3.70	−4.81	0.24 ± 0.03	46 ± 4
Nontargeted micelles	81.00 ± 3.00	192.00 ± 12.60	−2.12	0.20 ± 0.01	62 ± 1