Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling

Figure 2

Bayesian network and network motifs. (a1) Luminal-A gain Bayesian network; (a2) luminal-A gain network motif; (b1) luminal-A loss Bayesian network; (b2) luminal-A loss network motif; (c1) basal-like gain Bayesian network; (c2) basal-like gain network motif; (d1) basal-like loss Bayesian network; and (d2) basal-like loss network motif. In (a2–d2), each blue line indicates the interaction between two miRNAs; each red line indicates the relationship between miRNA and its target; and each green line indicates the interaction between two genes.