Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells

Figure 4

Inhibition of PI3K-dependent activation of ILK did not directly and negatively regulate MEF2C phosphorylation activity and MCK mRNA expression. (a), (b), and (c) Changes in ILK and MEF2C expression in LY294002/Cpd22-treated (L+/C+) C2C12 cells were not obvious; ILK (, ) phosphorylation levels decreased significantly and MEF2C phosphorylation levels increased slightly (, ). (d) MCK mRNA levels in C2C12 cells treated with LY294002/Cpd22 were increased (, ) compared with that in the control.

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