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BioMed Research International
Volume 2015, Article ID 749837, 10 pages
http://dx.doi.org/10.1155/2015/749837
Review Article

Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review

Department of Anesthesiology and Peri-Operative Medicine, Rutgers-New Jersey Medical School, 185 South Orange Avenue, South Orange, Newark, NJ 07103, USA

Received 16 December 2014; Accepted 16 March 2015

Academic Editor: Kok Eng Khor

Copyright © 2015 Brian M. Radvansky et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Johansen, L. Romundstad, C. S. Nielsen, H. Schirmer, and A. Stubhaug, “Persistent postsurgical pain in a general population: prevalence and predictors in the Tromso study,” Pain, vol. 153, no. 7, pp. 1390–1396, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Meera, “Pain and opioid dependence: is it a matter of concern,” Indian Journal of Palliative Care, vol. 17, no. 4, pp. S36–S38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Suzuki, “Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management,” Current Opinion in Anaesthesiology, vol. 22, no. 5, pp. 618–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Himmelseher and M. E. Durieux, “Ketamine for perioperative pain management,” Anesthesiology, vol. 102, no. 1, pp. 211–220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. E. F. Domino, P. Chodoff, and G. Corssen, “Pharmacologic effects of CI-581, a new dissociative anesthetic, in man,” Clinical Pharmacology and Therapeutics, vol. 6, pp. 279–291, 1965. View at Google Scholar · View at Scopus
  6. F. Aroni, N. Iacovidou, I. Dontas, C. Pourzitaki, and T. Xanthos, “Pharmacological aspects and potential new clinical applications of ketamine: reevaluation of an old drug,” Journal of Clinical Pharmacology, vol. 49, no. 8, pp. 957–964, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Persson, “Ketamine in pain management,” CNS Neuroscience & Therapeutics, vol. 19, no. 6, pp. 396–402, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Naughton, G. Clarke, O. F. O'Leary, J. F. Cryan, and T. G. Dinan, “A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action,” Journal of Affective Disorders, vol. 156, pp. 24–35, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. K. A. B. Lapidus, C. F. Levitch, A. M. Perez et al., “A randomized controlled trial of intranasal ketamine in major depressive disorder,” Biological Psychiatry, vol. 76, no. 12, pp. 970–976, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Azari, D. R. Lindsay, D. Briones, C. Clarke, T. Buchheit, and S. Pyati, “Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review,” CNS Drugs, vol. 26, no. 3, pp. 215–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. R. F. Bell, C. Eccleston, and E. A. Kalso, “Ketamine as an adjuvant to opioids for cancer pain,” The Cochrane Database of Systematic Reviews, no. 11, Article ID CD003351, 2012. View at Publisher · View at Google Scholar
  12. W. Leppert, “Ketamine in the management of cancer pain,” Journal of Clinical Oncology, vol. 31, no. 10, article 1374, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. J. H. Krystal, S. Madonick, E. Perry et al., “Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism,” Neuropsychopharmacology, vol. 31, no. 8, pp. 1793–1800, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Krupitsky, A. Burakov, T. Romanova, I. Dunaevsky, R. Strassman, and A. Grinenko, “Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up,” Journal of Substance Abuse Treatment, vol. 23, no. 4, pp. 273–283, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. E. M. Krupitsky, A. M. Burakov, I. V. Dunaevsky, T. N. Romanova, T. Y. Slavina, and A. Y. Grinenko, “Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence,” Journal of Psychoactive Drugs, vol. 39, no. 1, pp. 13–19, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. R. Jat and D. Chawla, “Ketamine for management of acute exacerbations of asthma in children,” The Cochrane Database of Systematic Reviews, vol. 11, Article ID CD009293, 2012. View at Google Scholar · View at Scopus
  17. K. R. Jat, C. Azad, and V. Guglani, “Use of ketamine for refractory wheezing in an infant,” Indian Pediatrics, vol. 49, no. 7, pp. 587–588, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Wang, Q. Wang, Y. Y. Yu, and W. S. Wang, “An effective dose of ketamine for eliminating pain during injection of propofol: a dose response study,” Annales Francaises d'Anesthesie et de Reanimation, vol. 32, no. 9, pp. e103–e106, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Katalinic, R. Lai, A. Somogyi, P. B. Mitchell, P. Glue, and C. K. Loo, “Ketamine as a new treatment for depression: a review of its efficacy and adverse effects,” The Australian and New Zealand Journal of Psychiatry, vol. 47, no. 8, pp. 710–727, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Oye, O. Paulsen, and A. Maurset, “Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors,” Journal of Pharmacology and Experimental Therapeutics, vol. 260, no. 3, pp. 1209–1213, 1992. View at Google Scholar · View at Scopus
  21. G. Mion and T. Villevieille, “Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings),” CNS Neuroscience & Therapeutics, vol. 19, no. 6, pp. 370–380, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J. A. Clements, W. S. Nimmo, and I. S. Grant, “Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans,” Journal of Pharmaceutical Sciences, vol. 71, no. 5, pp. 539–542, 1982. View at Publisher · View at Google Scholar · View at Scopus
  23. I. S. Grant, W. S. Nimmo, L. R. McNicol, and J. A. Clements, “Ketamine disposition in children and adults,” British Journal of Anaesthesia, vol. 55, no. 11, pp. 1107–1111, 1983. View at Publisher · View at Google Scholar · View at Scopus
  24. C. J. Woolf and S. W. N. Thompson, “The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states,” Pain, vol. 44, no. 3, pp. 293–299, 1991. View at Publisher · View at Google Scholar · View at Scopus
  25. L. A. Rosseland, A. Stubhaug, L. Sandberg, and H. Breivik, “Intra-articular (IA) catheter administration of postoperative analgesics. A new trial design allows evaluation of baseline pain, demonstrates large variation in need of analgesics, and finds no analgesic effect of IA ketamine compared with IA saline,” Pain, vol. 104, no. 1-2, pp. 25–34, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Niesters, N. Khalili-Mahani, C. Martini et al., “Effect of subanesthetic ketamine on intrinsic functional brain connectivity: a placebo-controlled functional magnetic resonance imaging study in healthy male volunteers,” Anesthesiology, vol. 117, no. 4, pp. 868–877, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Rogers, R. G. Wise, D. J. Painter, S. E. Longe, and I. Tracey, “An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging,” Anesthesiology, vol. 100, no. 2, pp. 292–301, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. D. J. Smith, R. L. Bouchal, C. A. DeSanctis et al., “Properties of the interaction between ketamine and opiate binding sites in vivo and in vitro,” Neuropharmacology, vol. 26, no. 9, pp. 1253–1260, 1987. View at Publisher · View at Google Scholar · View at Scopus
  29. O. Hustveit, A. Maurset, and I. Oye, “Interaction of the chiral forms of ketamine with opioid, phencyclidine, sigma and muscarinic receptors,” Pharmacology & Toxicology, vol. 77, no. 6, pp. 355–359, 1995. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Maurset, L. A. Skoglund, O. Hustveit, and I. Øye, “Comparison of ketamine and pethidine in experimental and postoperative pain,” Pain, vol. 36, no. 1, pp. 37–41, 1989. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Stella, A. Crescenti, and G. Torri, “Effect of naloxone on the loss of consciousness induced by I.V. anaesthetic agents in man,” British Journal of Anaesthesia, vol. 56, no. 4, pp. 369–373, 1984. View at Publisher · View at Google Scholar · View at Scopus
  32. D. D. F. Pacheco, T. R. L. Romero, and I. D. G. Duarte, “Central antinociception induced by ketamine is mediated by endogenous opioids and μ- And δ-opioid receptors,” Brain Research, vol. 1562, pp. 69–75, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. A. de Bartolomeis, C. Sarappa, E. F. Buonaguro et al., “Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 46, pp. 1–12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Subramaniam, B. Subramaniam, and R. A. Steinbrook, “Ketamine as adjuvant analgesic to opioids: a quantitative and qualitative systematic review,” Anesthesia and Analgesia, vol. 99, no. 2, pp. 482–495, 2004. View at Google Scholar · View at Scopus
  35. P. Lavand'homme, M. De Kock, and H. Waterloos, “Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery,” Anesthesiology, vol. 103, no. 4, pp. 813–820, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. A. K. Jha, N. Bhardwaj, S. Yaddanapudi, R. K. Sharma, and J. K. Mahajan, “A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair,” Paediatric Anaesthesia, vol. 23, no. 5, pp. 401–406, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. M. H. Eghbal, S. Taregh, A. Amin, and M. A. Sahmeddini, “Ketamine improves postoperative pain and emergence agitation following adenotonsillectomy in children. A randomized clinical trial,” Middle East Journal of Anesthesiology, vol. 22, no. 2, pp. 155–160, 2013. View at Google Scholar · View at Scopus
  38. H. K. Cho, K. W. Kim, Y. M. Jeong, H. S. Lee, Y. J. Lee, and S. H. Hwang, “Efficacy of ketamine in improving pain after tonsillectomy in children: meta-analysis,” PLoS ONE, vol. 9, no. 6, Article ID e101259, 2014. View at Publisher · View at Google Scholar
  39. R. Nitta, T. Goyagi, and T. Nishikawa, “Combination of oral clonidine and intravenous low-dose ketamine reduces the consumption of postoperative patient-controlled analgesia morphine after spine surgery,” Acta Anaesthesiologica Taiwanica, vol. 51, no. 1, pp. 14–17, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. B. A. Hadi, R. Daas, and R. Zelkó, “A randomized, controlled trial of a clinical pharmacist intervention in microdiscectomy surgery—low dose intravenous ketamine as an adjunct to standard therapy,” Saudi Pharmaceutical Journal, vol. 21, no. 2, pp. 169–175, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. S. H. Kim, S. I. Kim, S. Y. Ok et al., “Opioid sparing effect of low dose ketamine in patients with intravenous patient-controlled analgesia using fentanyl after lumbar spinal fusion surgery,” Korean Journal of Anesthesiology, vol. 64, no. 6, pp. 524–528, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. S. R. Pestieau, J. C. Finkel, M. M. Junqueira et al., “Prolonged perioperative infusion of low-dose ketamine does not alter opioid use after pediatric scoliosis surgery,” Paediatric Anaesthesia, vol. 24, no. 6, pp. 582–590, 2014. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Cengiz, D. Gokcinar, I. Karabeyoglu, H. Topcu, G. S. Cicek, and N. Gogus, “Intraoperative low-dose ketamine infusion reduces acute postoperative pain following total knee replacement surgery: a prospective, randomized double-blind placebo-controlled trial,” Journal of the College of Physicians and Surgeons—Pakistan, vol. 24, no. 5, pp. 299–303, 2014. View at Google Scholar · View at Scopus
  44. H. Guará Sobrinho, J. B. S. Garcia, J. W. Vasconcelos, J. C. A. Sousa, and L. S. G. Ferro, “Analgesic efficacy of the intra-articular administration of S(+)- ketamine in patients undergoing total knee arthroplasty,” Revista Brasileira de Anestesiologia, vol. 62, no. 5, pp. 665–675, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. R. C. D'Alonzo, E. Bennett-Guerrero, M. Podgoreanu, T. A. D'Amico, D. H. Harpole, and A. D. Shaw, “A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery,” Journal of Anesthesia, vol. 25, no. 5, pp. 672–678, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. N. Nesher, I. Serovian, N. Marouani, S. Chazan, and A. A. Weinbroum, “Ketamine spares morphine consumption after transthoracic lung and heart surgery without adverse hemodynamic effects,” Pharmacological Research, vol. 58, no. 1, pp. 38–44, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Abdolahi, H. A. Soltani, K. Montazeri, and B. Soleymani, “Preemptive low-dose of ketamine does not effective on anesthetic consumption, perioperative analgesic requirement and postoperative pain, nausea and vomiting in painful ophthalmic surgery,” Journal of Research in Medical Sciences, vol. 18, pp. 583–587, 2013. View at Google Scholar · View at Scopus
  48. E. Suppa, A. Valente, S. Catarci, B. A. Zanfini, and G. Draisci, “A study of low-dose S-ketamine infusion as ‘preventive’ pain treatment for cesarean section with spinal anesthesia: benefits and side effects,” Minerva Anestesiologica, vol. 78, no. 7, pp. 774–781, 2012. View at Google Scholar · View at Scopus
  49. J. Zakine, D. Samarcq, E. Lorne et al., “Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study,” Anesthesia & Analgesia, vol. 106, no. 6, pp. 1856–1861, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. M. de Kock, P. Lavand'homme, and H. Waterloos, “'Balanced analgesia' in the perioperative period: Is there a place for ketamine?” Pain, vol. 92, no. 3, pp. 373–380, 2001. View at Publisher · View at Google Scholar · View at Scopus
  51. K. Laskowski, A. Stirling, W. P. McKay, and H. J. Lim, “A systematic review of intravenous ketamine for postoperative analgesia,” Canadian Journal of Anesthesia, vol. 58, no. 10, pp. 911–923, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. N. Elia and M. R. Tramèr, “Ketamine and postoperative pain—a quantitative systematic review of randomised trials,” Pain, vol. 113, no. 1-2, pp. 61–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  53. C. J. L. McCartney, A. Sinha, and J. Katz, “A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia,” Anesthesia & Analgesia, vol. 98, no. 5, pp. 1385–1400, 2004. View at Google Scholar · View at Scopus
  54. M. Thomas, I. Tennant, R. Augier, G. Gordon-Strachan, and H. Harding, “The role of pre-induction ketamine in the management of postoperative pain in patients undergoing elective gynaecological surgery at the University Hospital of the West Indies,” The West Indian Medical Journal, vol. 61, pp. 224–229, 2012. View at Google Scholar · View at Scopus
  55. S. Bilgen, Ö. Köner, H. Türe, F. Menda, C. Fiçicioǧlu, and B. Aykaç, “Effect of three different doses of ketamine prior to general anaesthesia on postoperative pain following caesarean delivery: a prospective randomized study,” Minerva Anestesiologica, vol. 78, no. 4, pp. 442–449, 2012. View at Google Scholar · View at Scopus
  56. J. Katz, R. Schmid, D. G. Snijdelaar, T. J. Coderre, C. J. L. McCartney, and A. Wowk, “Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use,” Pain, vol. 110, no. 3, pp. 707–718, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. C. J. A. Morgan and H. V. Curran, “Ketamine use: a review,” Addiction, vol. 107, no. 1, pp. 27–38, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. R. J. Strayer and L. S. Nelson, “Adverse events associated with ketamine for procedural sedation in adults,” The American journal of emergency medicine, vol. 26, no. 9, pp. 985–1028, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. H. S. Smith, “Ketamine-induced urologic insult (KIUI),” Pain Physician, vol. 13, no. 6, pp. E343–E346, 2010. View at Google Scholar · View at Scopus
  60. I. M. Noppers, M. Niesters, L. P. H. J. Aarts et al., “Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases,” Pain, vol. 152, no. 9, pp. 2173–2178, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. A. C. Scallet, L. C. Schmued, W. Slikker Jr. et al., “Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons,” Toxicological Sciences, vol. 81, no. 2, pp. 364–370, 2004. View at Publisher · View at Google Scholar · View at Scopus
  62. V. Jevtovic-Todorovic, D. F. Wozniak, N. D. Benshoff, and J. W. Olney, “A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide,” Brain Research, vol. 895, no. 1-2, pp. 264–267, 2001. View at Publisher · View at Google Scholar · View at Scopus
  63. C. Dong and K. J. S. Anand, “Developmental neurotoxicity of ketamine in pediatric clinical use,” Toxicology Letters, vol. 220, no. 1, pp. 53–60, 2013. View at Publisher · View at Google Scholar · View at Scopus
  64. M. G. Paule, M. Li, R. R. Allen et al., “Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys,” Neurotoxicology and Teratology, vol. 33, no. 2, pp. 220–230, 2011. View at Publisher · View at Google Scholar · View at Scopus
  65. L. C. Chang, S. R. Raty, J. Ortiz, N. S. Bailard, and S. J. Mathew, “The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries,” CNS Neuroscience & Therapeutics, vol. 19, no. 6, pp. 390–395, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. K. Michalczyk, J. E. Sullivan, and J. W. Berkenbosch, “Pretreatment with midazolam blunts the rise in intracranial pressure associated with ketamine sedation for lumbar puncture in children,” Pediatric Critical Care Medicine, vol. 14, no. 3, pp. e149–e155, 2013. View at Publisher · View at Google Scholar · View at Scopus
  67. N. Gaspard, B. Foreman, L. M. Judd et al., “Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study,” Epilepsia, vol. 54, no. 8, pp. 1498–1503, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. N. Karpinski, J. Dunn, L. Hansen, and E. Masliah, “Subpial vacuolar myelopathy after intrathecal ketamine: report of a case,” Pain, vol. 73, no. 1, pp. 103–105, 1997. View at Publisher · View at Google Scholar · View at Scopus
  69. E. B. Perry Jr., J. A. Cramer, H.-S. Cho et al., “Psychiatric safety of ketamine in psychopharmacology research,” Psychopharmacology, vol. 192, no. 2, pp. 253–260, 2007. View at Publisher · View at Google Scholar · View at Scopus