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BioMed Research International
Volume 2015, Article ID 752850, 10 pages
http://dx.doi.org/10.1155/2015/752850
Research Article

The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea

Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou 510080, China

Received 11 May 2015; Revised 23 October 2015; Accepted 2 November 2015

Academic Editor: Leon Spicer

Copyright © 2015 Baoguo Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Tu, M. A. Budzinska, A. E. Maczurek et al., “Novel aspects of the liver microenvironment in hepatocellular carcinoma pathogenesis and development,” International Journal of Molecular Sciences, vol. 15, no. 6, pp. 9422–9458, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Du, “Clinical observation on treating 52 cases of primary liver cancer diarrhea with Zuozhu Daxi plus Fuzi Lizhong pill,” Clinical Journal of Chinese Medicine, vol. 3, no. 13, pp. 35–37, 2011 (Chinese). View at Google Scholar
  3. Z. Xu, “An analysis of 40 cases of cirrhosis-induced primary hepatocellular carcinoma with diarrhea as the first symptom,” Clinical Focus, vol. 17, no. 19, pp. 520–521, 2002 (Chinese). View at Google Scholar
  4. J. Bruix, G. J. Gores, and V. Mazzaferro, “Hepatocellular carcinoma: clinical frontiers and perspectives,” Gut, vol. 63, no. 5, pp. 844–855, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Pando, B. Shtaif, M. Phillip, and G. Gat-Yablonski, “A serum component mediates food restriction-induced growth attenuation,” Endocrinology, vol. 155, no. 3, pp. 932–940, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. R. L. Koretz, “The evidence for the use of nutritional support in liver disease,” Current Opinion in Gastroenterology, vol. 30, no. 2, pp. 208–214, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Nishikawa and Y. Osaki, “Clinical significance of therapy using branched-chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma,” Hepatology Research, vol. 44, no. 2, pp. 149–158, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. A. K. Taylor, W. Cao, K. P. Vora et al., “Protein energy malnutrition decreases immunity and increases susceptibility to influenza infection in mice,” Journal of Infectious Diseases, vol. 207, no. 3, pp. 501–510, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Nezu and K. Nakahara, “Role of malnutrition on immunity,” Nippon Rinsho, vol. 52, no. 2, pp. 410–414, 1994. View at Google Scholar · View at Scopus
  10. T. Muraoka, K. Shirouzu, H. Ozasa et al., “The effect of starvation on blood stream cancer cell metastasis to the liver in rat after laparotomy,” Kurume Medical Journal, vol. 60, no. 2, pp. 59–66, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Obaidat, M. Roth, and B. Hagenbuch, “The expression and function of organic anion transporting polypeptides in normal tissues and in cancer,” Annual Review of Pharmacology and Toxicology, vol. 52, pp. 135–151, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. N. F. Smith, W. D. Figg, and A. Sparreboom, “Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination,” Expert Opinion on Drug Metabolism and Toxicology, vol. 1, no. 3, pp. 429–445, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. J. L. Wright, E. M. Kwon, E. A. Ostrander et al., “Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes,” Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 4, pp. 619–627, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Muto, T. Onogawa, T. Suzuki et al., “Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma,” Cancer Science, vol. 98, no. 10, pp. 1570–1576, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. G. D. Kruh and M. G. Belinsky, “The MRP family of drug efflux pumps,” Oncogene, vol. 22, no. 47, pp. 7537–7552, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. C. G. Dietrich, D. R. de Waart, R. Ottenhoff, I. G. Schoots, and R. P. J. Oude Elferink, “Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats,” Molecular Pharmacology, vol. 59, no. 5, pp. 974–980, 2001. View at Google Scholar · View at Scopus
  17. W.-H. Li, Y. Cui, and J.-R. Zhu, “Methylated oligonucleotide inhibiting expression of human MRP2 and reversing multidrug resistance in hepatocellular carcinoma Cell HepG2,” Chinese Journal of Cancer, vol. 23, no. 8, pp. 900–904, 2004 (Chinese). View at Google Scholar · View at Scopus
  18. A.-Z. Pan, Y.-K. Hao, Y.-W. Lin et al., “Study on the expression of organic anion transporting polypeptide (oatp2a1) in rat with spleen deficiency syndrome and the exploration of clinical aignificance,” Chinese Medicine, vol. 2, no. 3, pp. 109–114, 2011. View at Publisher · View at Google Scholar
  19. L.-R. Yin, Z.-X. Chen, S.-J. Zhang, B.-G. Sun, Y.-D. Liu, and H.-Z. Huang, “Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction,” World Journal of Gastroenterology, vol. 14, no. 1, pp. 108–113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Yang, T. Xiang, S. Zhang et al., “Effect of polypeptide 2B1 on condition of dampness pattern in rats in terms of traditional Chinese medicine,” Journal of Traditional Chinese Medicine, vol. 34, no. 2, pp. 214–220, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. A. A. Dreifuss, A. L. Bastos-Pereira, I. A. Fabossi et al., “Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumour by modulating oxidative stress and not by alkaloid activity,” PLoS ONE, vol. 8, no. 2, Article ID e54618, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. B. W. Konicek, J. R. Stephens, A. M. McNulty et al., “Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases,” Cancer Research, vol. 71, no. 5, pp. 1849–1857, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Ogawaa, H. Tashiroa, Y. Miyataa et al., “Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model,” American Journal of Transplantation, vol. 7, no. 2, pp. 347–355, 2007. View at Publisher · View at Google Scholar
  24. F. O. Duarte, M. Sene-Fiorese, N. C. Cheik et al., “Food restriction and refeeding induces changes in lipid pathways and fat deposition in the adipose and hepatic tissues in rats with diet-induced obesity,” Experimental Physiology, vol. 97, no. 7, pp. 882–894, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Chen, B.-G. Sun, S.-J. Zhang, Z.-X. Chen, C. F. Hardi, and T. Xiang, “Observations of TCRV β gene expression in rats with dampness syndrome,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 373608, 5 pages, 2014. View at Publisher · View at Google Scholar
  26. F. Pretto, C. Ghilardi, M. Moschetta et al., “Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle,” Oncotarget, vol. 20, no. 6, pp. 3043–3054, 2015. View at Publisher · View at Google Scholar
  27. J. L. Kenneth and D. S. Thomas, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar
  28. M. Jiang, W. Zhang, Z. Ma, and X. Gu, “Antinociception and prevention of hyperalgesia by intrathecaladministration of Ro 25-6981, a highly selective antagonist of the 2Bsubunit of N-methyl-D-aspartate receptor,” Pharmacology, Biochemistry and Behavior, vol. 112, pp. 56–63, 2013. View at Google Scholar
  29. M. Kaufhold, K. Schulz, D. Breljak et al., “Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3,” American Journal of Physiology—Renal Physiology, vol. 301, no. 5, pp. F1026–F1034, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Allikmets, B. Gerrard, A. Hutchinson, and M. Dean, “Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database,” Human Molecular Genetics, vol. 5, no. 10, pp. 1649–1655, 1996. View at Publisher · View at Google Scholar · View at Scopus
  31. C. F. Higgins, “ABC transporters: from microorganisms to man,” Annual Review of Cell Biology, vol. 8, pp. 67–113, 1992. View at Publisher · View at Google Scholar · View at Scopus
  32. A. T. Nies and D. Keppler, “The apical conjugate efflux pump ABCC2 (MRP2),” Pflugers Archiv European Journal of Physiology, vol. 453, no. 5, pp. 643–659, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Keppler and J. König, “Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver,” The FASEB Journal, vol. 11, no. 7, pp. 509–516, 1997. View at Google Scholar · View at Scopus
  34. J. König, A. T. Nies, Y. Cui, I. Leier, and D. Keppler, “Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance,” Biochimica et Biophysica Acta—Biomembranes, vol. 1461, no. 2, pp. 377–394, 1999. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Bonin, L. Pascolo, L. S. Crocé, G. Stanta, and C. Tiribelli, “Gene expression of ABC proteins in hepatocellular carcinoma, perineoplastic tissue, and liver diseases,” Molecular Medicine, vol. 8, no. 6, pp. 318–325, 2002. View at Google Scholar · View at Scopus
  36. G. Zollner, M. Wagner, P. Fickert et al., “Hepatobiliary transporter expression in human hepatocellular carcinoma,” Liver International, vol. 25, no. 2, pp. 367–379, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. X. Cheng, J. Maher, C. Chen, and C. D. Klaassen, “Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps),” Drug Metabolism and Disposition, vol. 33, no. 7, pp. 1062–1073, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Wlcek, M. Svoboda, J. Riha et al., “The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer,” Cancer Biology & Therapy, vol. 11, no. 9, pp. 801–811, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Vasuri, R. Golfieri, M. Fiorentino et al., “OATP 1B1/1B3 expression in hepatocellular carcinomas treated with orthotopic liver transplantation,” Virchows Archiv, vol. 459, no. 2, pp. 141–146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. S. R. Vavricka, D. Jung, M. Fried, U. Grützner, P. J. Meier, and G. A. Kullak-Ublick, “The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3β in hepatocellular carcinoma,” Journal of Hepatology, vol. 40, no. 2, pp. 212–218, 2004. View at Publisher · View at Google Scholar · View at Scopus