Evaluation of the Efficacy of a Bacteriophage in the Treatment of Pneumonia Induced by Multidrug Resistance Klebsiella pneumoniae in Mice

Figure 7

Cytokine assay of lung tissue after phage treatment of K. pneumoniae infection. Groups of 6 mice were inoculated via the intranasal route with 6 × 10⁷ CFU/mouse K. pneumoniae. PBS or phage 1513 (6 × 10⁷ PFU/mouse) was administered intranasally 2 h after infection. The mice were killed 24 h after infection, and the inflammatory cytokines of the lung homogenate were collected and detected. Cytokine concentrations were remarkably lower in the phage-treated group than in the control group. (a) TNF-α (). (b) IL-6 ().

(a)

(b)