Novel Method for Automated Analysis of Retinal Images: Results in Subjects with Hypertensive Retinopathy and CADASIL
Table 3
Sensitivity, specificity, and positive and negative predictive values of the retinal indices to classify subjects with hypertensive retinopathy or CADASIL.
Indices
Sensitivity
Specificity
PPV
NPV
HR versus controls
CADASIL versus controls
HR versus controls
CADASIL versus controls
HR versus controls
CADASIL versus controls
HR versus controls
CADASIL versus controls
AVR
68.8 (41.4–88.9)
54.5 (23.5–83.1)
87.5 (61.6–98.1)
90.9 (58.7–98.5)
84.6 (54.5–97.6)
85.7 (42.2–97.6)
73.7 (48.8–90.8)
66.7 (38.4–88.1)
Mean-D
62.5 (35.5–84.7)
99.9 (71.3–99.9)
68.8 (41.4–88.9)
36.4 (11.1–69.1)
66.7 (38.4–88.1)
61.1 (35.8–82.6)
64.7 (38.4–85.7)
99.9 (40.2–99.9)
TI
43.8 (19.8–70.1)
54.6 (23.5–83.1)
75.0 (47.6–92.6)
63.6 (30.1–88.9)
63.6 (30.1–88.9)
60.0 (26.4–87.6)
57.1 (34.0–78.1)
58.3 (27.7–84.7)
AVR + mean-D + TI
68.8 (41.4–88.9)
54.5 (23.5–83.1)
87.5 (61.6–98.1)
90.9 (58.7–98.5)
84.6 (54.5–97.6)
85.7 (42.2–97.6)
73.7 (48.8–90.8)
66.7 (38.4–88.1)
Results are expressed as % (95% CI). AVR: arteriole-to-venule ratio; HR: hypertensive retinopathy; mean-D: mean fractal dimension; NPV: negative predictive value; PPV: positive predictive value; TI: tortuosity index.
