Prevalence of Helicobacter pylori vacA, cagA, and iceA Genotypes in Cuban Patients with Upper Gastrointestinal Diseases
Table 2
Association of H. pylori subtypes/genotypes with endoscopic findings and age of patients.
Genotypes
Clinical status
Age groups
NUD
PUD
value
Group 1
Group 2
value
= 44 (%)
= 24 (%)
= 35 (%)
= 33 (%)
vacA
s1
31 (70.5)
19 (79.2)
0.249
23 (65.7)
27 (81.8)
0.008*
s2
11 (25.0)
3 (12.5)
12 (34.3)
2 (6.1)
s1-s2±
2 (4.5)
2 (8.3)
0 (0.0)
4 (12.1)
m1
20 (45.5)
15 (62.5)
0.179
17 (48.6)
18 (54.5)
0.622
m2
24 (54.5)
9 (37.5)
18 (51.4)
15 (45.5)
s1m1
20 (45.5)
14 (58.4)
0.095
17 (48.6)
17 (51.5)
0.589
s1m2
11 (25.0)
5 (20.8)
0.728
6 (17.1)
10 (30.4)
0.003*
s2m1
0 (0.0)
1 (4.2)
—
0 (0.0)
1 (3.0)
—
s2m2
11 (25.0)
2 (8.3)
0.395
12 (34.3)
1 (3.0)
0.016*
s1-s2m2±
2 (4.5)
2 (8.3)
0 (0.0)
4 (12.1)
cagA
cagA+
22 (50.0)
16 (66.7)
0.186
18 (51.4)
20 (60.6)
0.446
cagA−
22 (50.0)
8 (33.3)
17 (48.6)
13 (39.4)
iceA
iceA1
14 (31.8)
11 (45.8)
0.037*
12 (34.3)
13 (39.4)
0.455
iceA2
28 (63.6)
12 (50.0)
23 (65.7)
17 (51.5)
iceA1-iceA2±
2 (4.6)
1 (4.2)
0 (0.0)
3 (9.1)
Clinical status
NUD
—
—
28 (80)
16 (48.5)
0.007*
PUD
—
—
7 (20)
17 (51.5)
NUD: non-peptic ulcer dyspepsia. PUD: peptic ulcer disease. Group 1: under 40 years old. Group 2: those within 40 years and older. *Statistically significant ( < 0.05). ±Strains with multiple genotypes and seven strains recovered from gastric corpus were excluded from analysis. (—) This analysis is impossible to do.
