Nanoparticle Probes for Structural and Functional Photoacoustic Molecular Tomography

Figure 5

Differences on photoacoustic properties generated from conjugated polymer nanoparticles (SPN1), carbon nanotubes (SWCNTs), and gold nanorods (GNRs). (a) The photoacoustic intensity produced by different nanoparticles based on the same mass (25 μg mL⁻¹) (top) and molar (48 nM) (bottom) concentrations in an agar phantom. (b) The photoacoustic intensity regarding indicated nanoparticles in agar phantoms versus the number of laser pulses. (c) The photoacoustic intensity of the nanoparticle-matrigel targets (inclusions) (30 μL) in the subcutaneous dorsal space of living mice as a function of nanoparticle mass concentration. (d) The overlaid photoacoustic/ultrasound images of the nanoparticle-matrigel targets in mice at a concentration of 8 μg mL⁻¹. Reproduced with permission from [24].

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