Magnetic Resonance Imaging of Atherosclerosis Using CD81-Targeted Microparticles of Iron Oxide in Mice

Figure 3

Concentration dependence of CD81-MPIO binding. Various concentrations of CD81-MPIO were used for examining binding efficiency. 1 × 10⁵ (a), 1 × 10⁶ (b), and 1 × 10⁷ (c) CD81-MPIO particles were used for examining binding efficiency to the PMS-stimulated bEnd.3 cells. (d) 1 × 10⁷ CD81-MPIO was used for the nonstimulated bEnd.3 cells. (e) Quantitative assay of the number of MPIO adhered onto bEnd.3 cells from six random view fields (bar = 20 μm).

(a)

(b)

(c)

(d)

(e)