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BioMed Research International
Volume 2015, Article ID 762349, 14 pages
Research Article

Regulation of Cell Cycle Regulators by SIRT1 Contributes to Resveratrol-Mediated Prevention of Pulmonary Arterial Hypertension

1Department of Rheumatology, Peking Union Medical College Hospital, Beijing 100032, China
2State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China
3Department of Cardiology, Peking Union Medical College Hospital, Beijing 100730, China

Received 9 October 2014; Accepted 21 December 2014

Academic Editor: James C. C. Wei

Copyright © 2015 Shuang Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Expression of CDK2 and CDK4 have no remarkable change in PDGF-BB treated HPASMCs. Overexpression of SIRT1 decreases CDK2 protein level but not affects CDK4 expression. SIRT1 expression level and the effect of resveratrol in MCT-induced PAH rats. Expression of Cyclin E has no remarkable change in lungs of PAH rats.

  1. Supplementary Material