Figure 4: The DNA vaccine attenuated bone erosion in CIA mice. Mice were injected intradermally with bovine type II collagen to induce arthritis (/group). (a-b) The incidence of arthritis and clinical score were recorded until day 39. (c–f) Representative joints on the day of sacrifice were analyzed with HE staining, Micro-CT images, BMD analysis, and TB staining images. Bars indicate 500 μm and 200 μm. Data are expressed as the mean ± SEM. .