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BioMed Research International
Volume 2015 (2015), Article ID 768071, 7 pages
http://dx.doi.org/10.1155/2015/768071
Review Article

The Role of Dendritic Cells in Fibrosis Progression in Nonalcoholic Fatty Liver Disease

1Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 14080 Mexico, DF, Mexico
2Liver Research Unit, Medica Sur Clinic & Foundation, 14050 Mexico, DF, Mexico
3Department of Gastroenterology, National Medical Center “20 Noviembre”, 03229 Mexico, DF, Mexico

Received 26 February 2015; Revised 1 June 2015; Accepted 14 June 2015

Academic Editor: Jantje M. Gerdes

Copyright © 2015 Paloma Almeda-Valdes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. López-Velázquez, K. V. Silva-Vidal, G. Ponciano-Rodríguez et al., “The prevalence of nonalcoholic fatty liver disease in the Americas,” Annals of Hepatology, vol. 13, no. 2, pp. 166–178, 2014. View at Google Scholar · View at Scopus
  2. P. Babusik, M. Bilal, and I. Duris, “Nonalcoholic fatty liver disease of two ethnic groups in Kuwait: comparison of prevalence and risk factors,” Medical Principles and Practice, vol. 21, no. 1, pp. 56–62, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Bedogni, L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, and S. Bellentani, “Prevalence of and risk factors for nonalcoholic fatty liver disease: the dionysos nutrition and liver study,” Hepatology, vol. 42, no. 1, pp. 44–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Caballería, G. Pera, M. A. Auladell et al., “Prevalence and factors associated with the presence of nonalcoholic fatty liver disease in an adult population in Spain,” European Journal of Gastroenterology and Hepatology, vol. 22, no. 1, pp. 24–32, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Ratziua, S. Bellentanib, H. Cortez-Pintoc, C. Dayd, and G. Marchesinie, “A position statement on NAFLD/NASH based on the EASL 2009 special conference,” Journal of Hepatology, vol. 53, no. 2, pp. 372–384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. G. Fan, J. D. Jia, Y. M. Li et al., “Guidelines for the diagnosis and management of nonalcoholic fatty liver disease: update 2010: (published in Chinese on Chinese Journal of Hepatology 2010; 18:163–166),” Journal of Digestive Diseases, vol. 12, no. 1, pp. 38–44, 2011. View at Publisher · View at Google Scholar
  7. N. Méndez-Sánchez, M. Arrese, D. Zamora-Valdés, and M. Uribe, “Current concepts in the pathogenesis of nonalcoholic fatty liver disease,” Liver International, vol. 27, no. 4, pp. 423–433, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Handa and K. V. Kowdley, “Dendritic cells in NASH: friend or foe?” Annals of Hepatology, vol. 12, no. 3, pp. 508–509, 2013. View at Google Scholar · View at Scopus
  9. W. Hsu, S.-A. Shu, E. Gershwin, and Z.-X. Lian, “The current immune function of hepatic dendritic cells.,” Cellular & Molecular Immunology, vol. 4, no. 5, pp. 321–328, 2007. View at Google Scholar · View at Scopus
  10. A. W. Thomson and P. A. Knolle, “Antigen-presenting cell function in the tolerogenic liver environment,” Nature Reviews Immunology, vol. 10, no. 11, pp. 753–766, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. A. H. Rahman and C. Aloman, “Dendritic cells and liver fibrosis,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1832, no. 7, pp. 998–1004, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Kelly, E. J. Ryan, and C. O'Farrelly, “Reply to: ‘dendritic cell subset composition in the human liver is more complex than it seems’,” Journal of Hepatology, vol. 60, no. 5, pp. 1098–1099, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. I. Jomantaite, N. Dikopoulos, A. Kröger et al., “Hepatic dendritic cell subsets in the mouse,” European Journal of Immunology, vol. 34, no. 2, pp. 355–365, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Chen, E. Calomeni, J. Wen, K. Ozato, R. Shen, and J.-X. Gao, “Natural killer dendritic cells are an intermediate of developing dendritic cells,” Journal of Leukocyte Biology, vol. 81, no. 6, pp. 1422–1433, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. V. Kumar, “NKT-cell subsets: promoters and protectors in inflammatory liver disease,” Journal of Hepatology, vol. 59, no. 3, pp. 618–620, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Guebre-Xabier, S. Yang, H. Z. Lin, R. Schwenk, U. Krzych, and A. M. Diehl, “Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage,” Hepatology, vol. 31, no. 3, pp. 633–640, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Kremer, E. Thomas, R. J. Milton et al., “Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis,” Hepatology, vol. 51, no. 1, pp. 130–141, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-T. Zhan and W. An, “Roles of liver innate immune cells in nonalcoholic fatty liver disease,” World Journal of Gastroenterology, vol. 16, no. 37, pp. 4652–4660, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. W.-K. Syn, Y. H. Oo, T. A. Pereira et al., “Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease,” Hepatology, vol. 51, no. 6, pp. 1998–2007, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Trobonjaca, F. Leithäuser, P. Möller, R. Schirmbeck, and J. Reimann, “Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-gamma release by liver NKT cells,” The Journal of Immunology, vol. 167, no. 3, pp. 1413–1422, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Boltjes and F. van Wijk, “Human dendritic cell functional specialization in steady-state and inflammation,” Frontiers in Immunology, vol. 5, article 131, Article ID Article 131, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Banchereau and R. M. Steinman, “Dendritic cells and the control of immunity,” Nature, vol. 392, no. 6673, pp. 245–252, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. I. Mellman and R. M. Steinman, “Dendritic cells: specialized and regulated antigen processing machines,” Cell, vol. 106, no. 3, pp. 255–258, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Schuler and R. M. Steinman, “Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro,” The Journal of Experimental Medicine, vol. 161, no. 3, pp. 526–546, 1985. View at Publisher · View at Google Scholar · View at Scopus
  25. P. G. Holt, M. A. Schon-Hegrad, J. Oliver, B. J. Holt, and P. G. McMenamin, “A contiguous network of dendritic antigen-presenting cells within the respiratory epithelium,” International Archives of Allergy and Applied Immunology, vol. 91, no. 2, pp. 155–159, 1990. View at Publisher · View at Google Scholar · View at Scopus
  26. D. N. J. Hart and J. W. Fabre, “Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissue of rat heart and other tissues, but not brain,” Journal of Experimental Medicine, vol. 154, no. 2, pp. 347–361, 1981. View at Publisher · View at Google Scholar · View at Scopus
  27. D. N. J. Hart and J. L. McKenzie, “Isolation and characterization of human tonsil dendritic cells,” Journal of Experimental Medicine, vol. 168, no. 1, pp. 157–170, 1988. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Bujdoso, J. Hopkins, B. M. Dutia, P. Young, and I. McConnell, “Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage,” The Journal of Experimental Medicine, vol. 170, no. 4, pp. 1285–1302, 1989. View at Publisher · View at Google Scholar · View at Scopus
  29. M. V. Dhodapkar, R. M. Steinman, M. Sapp et al., “Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells,” The Journal of Clinical Investigation, vol. 104, no. 2, pp. 173–180, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. R. M. Steinman, S. Turley, I. Mellman, and K. Inaba, “The induction of tolerance by dendritic cells that have captured apoptotic cells,” Journal of Experimental Medicine, vol. 191, no. 3, pp. 411–416, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Hawiger, K. Inaba, Y. Dorsett et al., “Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo,” Journal of Experimental Medicine, vol. 194, no. 6, pp. 769–779, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. C. R. Sousa, P. D. Stahl, and J. M. Austyn, “Phagocytosis of antigens by Langerhans cells in vitro,” Journal of Experimental Medicine, vol. 178, no. 2, pp. 509–519, 1993. View at Publisher · View at Google Scholar · View at Scopus
  33. W. Jian, W. J. Swiggard, C. Heufler et al., “The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing,” Nature, vol. 375, no. 6527, pp. 151–155, 1995. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Pierre, S. J. Turley, E. Gatti et al., “Developmental regulation of MHC class II transport in mouse dendritic cells,” Nature, vol. 388, no. 6644, pp. 787–792, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Inaba, S. Turley, T. Iyoda et al., “The formation of immunogenic major histocompatibility complex class II-peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli,” The Journal of Experimental Medicine, vol. 191, no. 6, pp. 927–936, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. R. M. Steinman and M. C. Nussenzweig, “Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 1, pp. 351–358, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. C. Buelens, V. Verhasselt, D. de Groote, K. Thielemans, M. Goldman, and F. Willems, “Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10,” European Journal of Immunology, vol. 27, no. 8, pp. 1848–1852, 1997. View at Publisher · View at Google Scholar · View at Scopus
  38. T. A. Springer, “Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm,” Cell, vol. 76, no. 2, pp. 301–314, 1994. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Caux, C. Massacrier, B. Vanbervliet et al., “Activation of human dendritic cells through CD40 cross-linking,” Journal of Experimental Medicine, vol. 180, no. 4, pp. 1263–1272, 1994. View at Publisher · View at Google Scholar · View at Scopus
  40. S. J. Turley, K. Inaba, W. S. Garrett et al., “Transport of peptide-MHC class II complexes in developing dendritic cells,” Science, vol. 288, no. 5465, pp. 522–527, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. S.-Y. Tseng, M. Otsuji, K. Gorski et al., “B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells,” Journal of Experimental Medicine, vol. 193, no. 7, pp. 839–845, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Ebner, G. Ratzinger, B. Krösbacher et al., “Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4,” The Journal of Immunology, vol. 166, no. 1, pp. 633–641, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Sozzani, P. Allavena, A. Vecchi, and A. Mantovani, “The role of chemokines in the regulation of dendritic cell trafficking,” Journal of Leukocyte Biology, vol. 66, no. 1, pp. 1–9, 1999. View at Google Scholar · View at Scopus
  44. F. Sallusto, P. Schaerli, P. Loetscher et al., “Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation,” European Journal of Immunology, vol. 28, no. 9, pp. 2760–2769, 1998. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Cella, A. Engering, V. Pinet, J. Pieters, and A. Lanzavecchia, “Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells,” Nature, vol. 388, no. 6644, pp. 782–787, 1997. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Reis E Sousa, S. Hieny, T. Scharton-Kersten et al., “In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas,” Journal of Experimental Medicine, vol. 186, no. 11, pp. 1819–1829, 1997. View at Publisher · View at Google Scholar · View at Scopus
  47. M. V. Dhodapkar, J. Krasovsky, R. M. Steinman, and N. Bhardwaj, “Mature dendritic cells boost functionally superior CD8+ T-cell in humans without foreign helper epitopes,” The Journal of Clinical Investigation, vol. 105, no. 6, pp. R9–R14, 2000. View at Google Scholar · View at Scopus
  48. C. P. Larsen, R. M. Steinman, M. Witmer-Pack, D. F. Hankins, P. J. Morris, and J. M. Austyn, “Migration and maturation of Langerhans cells in skin transplants and explants,” Journal of Experimental Medicine, vol. 172, no. 5, pp. 1483–1493, 1990. View at Publisher · View at Google Scholar · View at Scopus
  49. A. H. Enk and S. I. Katz, “Early molecular events in the induction phase of contact sensitivity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 4, pp. 1398–1402, 1992. View at Publisher · View at Google Scholar · View at Scopus
  50. G. Schuler and R. M. Steinman, “Dendritic cells as adjuvants for immune-mediated resistance to tumors,” Journal of Experimental Medicine, vol. 186, no. 8, pp. 1183–1187, 1997. View at Publisher · View at Google Scholar · View at Scopus
  51. A. Bender, L. K. Bui, M. A. V. Feldman, M. Larsson, and N. Bhardwaj, “Inactivated influenza virus, when presented on dendritic cells, elicits human CD8+ cytolytic T cell responses,” Journal of Experimental Medicine, vol. 182, no. 6, pp. 1663–1671, 1995. View at Publisher · View at Google Scholar · View at Scopus
  52. R. Xu, Z. Zhang, and F.-S. Wang, “Liver fibrosis: mechanisms of immune-mediated liver injury,” Cellular and Molecular Immunology, vol. 9, no. 4, pp. 296–301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. R. Bataller and D. A. Brenner, “Liver fibrosis,” The Journal of Clinical Investigation, vol. 115, no. 2, pp. 209–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. R. Fischer, A. Cariers, R. Reinehr, and D. Häussinger, “Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells,” Gastroenterology, vol. 123, no. 3, pp. 845–861, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. Y.-H. Paik, R. F. Schwabe, R. Bataller, M. P. Russo, C. Jobin, and D. A. Brenner, “Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells,” Hepatology, vol. 37, no. 5, pp. 1043–1055, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. K. Iwaisako, K. Taura, Y. Koyama, K. Takemoto, and M. Asagiri, “Strategies to detect hepatic myofibroblasts in liver cirrhosis of different etiologies,” Current Pathobiology Reports, vol. 2, no. 4, pp. 209–215, 2014. View at Publisher · View at Google Scholar
  57. H. Sahin and H. E. Wasmuth, “Chemokines in tissue fibrosis,” Biochimica et Biophysica Acta, vol. 1832, no. 7, pp. 1041–1048, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. V. Lukacs-Kornek and D. Schuppan, “Dendritic cells in liver injury and fibrosis: shortcomings and promises,” Journal of Hepatology, vol. 59, no. 5, pp. 1124–1126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. M. K. Connolly, A. S. Bedrosian, J. Mallen-St. Clair et al., “In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-α,” The Journal of Clinical Investigation, vol. 119, no. 11, pp. 3213–3225, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. J. Ibrahim, A. H. Nguyen, A. Rehman et al., “Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver,” Gastroenterology, vol. 143, no. 4, pp. 1061–1072, 2012. View at Publisher · View at Google Scholar · View at Scopus
  61. J. Jiao, D. Sastre, M. I. Fiel et al., “Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression,” Hepatology, vol. 55, no. 1, pp. 244–255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. J. R. Henning, C. S. Graffeo, A. Rehman et al., “Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice,” Hepatology, vol. 58, no. 2, pp. 589–602, 2013. View at Publisher · View at Google Scholar · View at Scopus