Effect of Metformin on Viability, Morphology, and Ultrastructure of Mouse Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells and Balb/3T3 Embryonic Fibroblast Cell Line

Figure 8

mRNA expression of H19, insulin-like growth factor 2 (IGF2), its receptor (IGF2R), and Oct-4 in BMSCs (a) and Balb/3T3 cell line (b) in control and experimental cultures. The level of expression of all genes was calculated in relation to the housekeeping gene, beta 2 microglobulin (2m). Results are presented as the mean of three independent experiments ± standard deviation (±SD). Significance was determined by one-way ANOVA test (). Description of observed relationships was included in the main body of the paper.

(a)

(b)