Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common Tissue

Figure 4

Jaccard coefficient. (a) The average Jaccard coefficient of common-motif TF pairs in TSN (0.0568) was significantly greater than that of 1000 times randomly shuffled TFs (0.0399) at the subpathway level (experiential ). (b) The average Jaccard coefficient of real common-motif TF pairs was significantly higher than that of random TF pairs (0.1045 versus 0.0723, experiential ) at the pathway level. (c) The average Jaccard coefficient of real common-motif TF pairs was significantly higher than that of random TF pairs (0.3867 versus 0.3649, experiential, ) at the pathway class level. The result implied that TFs with similar DNA motifs regulated the cofunctional subpathway. (d) The average Jaccard coefficient of real common-family TF pairs in TSN (0.1239) was significantly higher than that of random TF pairs (0.005) at the subpathway level (experiential ). (e) The average Jaccard coefficient of real common-family TF pairs in TSN (0.1478) was significantly higher than that of random TF pairs (0.0402) at the pathway level (experiential ). (f) The average Jaccard coefficient of real common-family TF pairs in TSN (0.4088) was significantly higher than that of random TF pairs (0.2420) at the pathway class level (experiential ). The result implied that common-family TFs regulated the cofunctional subpathway. (g) The average Jaccard coefficient of real common-family TF pairs in TSN (0.0289) was significantly higher than that of random TF pairs (0.0048) at the subpathway level (experiential ). (h) The average Jaccard coefficient of real common-family TF pairs in TSN (0.0935) was significantly higher than that of random TF pairs (0.0386) at the pathway level (experiential ). (i) The average Jaccard coefficient of real common-family TF pairs in TSN (0.4779) was significantly higher than that of random TF pairs (0.2413) at the pathway class level (experiential ).

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