Physiological Impact of Abnormal Lipoxin A₄ Production on Cystic Fibrosis Airway Epithelium and Therapeutic Potential

Figure 1

Lipoxin A₄ biosynthesis by trans-cellular cooperation in the airways. The neutrophil donates LTA₄ intermediate formed by the action of 5 lipoxygenase (5-LO) on arachidonic acid (AA) to the acceptor airway epithelial cell or alveolar macrophage whereby 15 lipoxygenase (15-LO) catalyses LXA₄ formation (brown arrows). Airway epithelial cell or alveolar macrophage 15-LO activity catalyses the conversion of AA to 15S-HETE which is donated to the acceptor neutrophil and converted to LXA₄ by 5-LO catalysis (blue arrows).