Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells

Figure 9

Paricalcitol inhibits aldosterone-mediated activation of ERK and STAT-1 pathway. HK2 cells were preincubated with paricalcitol (12 μmol/L) for 48 hours before stimulation with 1 μmol/L Aldo for 15 min. Figure (a) shows a representative experiment and in (b) quantification of p-ERK and p-STAT1 expressed as mean ± SEM of 3 independent experiments. versus control. ^# versus Aldo.

(a)

(b)