Alpha-Mangostin Attenuation of Hyperglycemia-Induced Ocular Hypoperfusion and Blood Retinal Barrier Leakage in the Early Stage of Type 2 Diabetes Rats

Figure 2

(a) Ocular blood flow (OBF) and retinal Evans blue dye leakage (blood retinal barrier leakage; BRB) and (b) correlation between OBF and BRB which were monitored in normal control rats (CON), type 2 diabetic rats (DM2), α-MG supplemented normal control rats (CON-MG), and α-MG supplemented type 2 diabetic rats (DM2-MG). Values are presented as mean ± SEM. ^+,+++ indicate significant differences compared to the CON rats at and , respectively. ^### indicates significant difference compared to the DM2 rats at . The linear regression equation was expressed as (), where is ocular blood flow, is blood retinal barrier leakage, and is correlation coefficient.

(a)

(b)