Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model

Figure 4

Effect of ciclamilast on the cytokine levels in paw tissue of rats with AIA. Rats with AIA were treated with vehicle or 1, 3, or 10 mg/kg ciclamilast or 0.1 mg/kg MTX via oral gavage from days 0 to 28 after adjuvant induction. Twenty-four hours after the last administration of ciclamilast, rats were killed. The subcutaneous tissue of the right hind paw and the surrounding tarsotibial joints were removed, homogenized, and used for assessment of cytokine levels by ELISA. Statistical analysis was performed by one-way ANOVA (Dunnett’s method) or Mann-Whitney -test. , versus control; , versus vehicle rats. Data represent the mean ± S.E.M. (/group).