Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model

Figure 5

Inhibition of carrageenan-induced paw edema in rats by ciclamilast. Ciclamilast (Cic) or indomethacin (Indo) was administered p.o. 30 min after intraplantar injection of carrageenan (100 μL of 1% carrageenan) into the left hind paw pad. At the specified times, paw volume was measured by a water-replacement plethysmometer. Statistical analysis was performed by one-way ANOVA (Dunnett’s method) or Mann-Whitney -test. , and versus vehicle group. Data represent the mean ± S.E.M. (/group).