Increased Circulating Advanced Oxidation Protein Products and High-Sensitive Troponin T in Cirrhotic Patients with Chronic Hepatitis C: A Preliminary Report
Table 2
Plasma concentrations of AOPPs-albumin and hs-TnT in cirrhotic patients with chronic HCV infection.
Healthy controls
Child-Pugh
Child-Pugh
Child-Pugh
A
B
C
()
40
34
34
20
Age (years)
55 (29–56)
54 (21–74)
58 (24–71)
56 (29–69)
Albumin (g/L)
45 (36–57)
34 (28–45)
30 (20–40)
25 (16–32)
Bilirubin (mg/dL)
0.7 (0.6–0.9)
1.01 (1.02–1.03)
1.56 (1.0–2.0)
2.15 (1.1–3.6)
INR (0.8–1.1)
—
0.9 (0.8–1.09)
1.2 (1.1–1.3)
2.3+ (1.6–2.9)
MELD score (6–8)
—
7 (5–10)
9 (8–13)
14++ (10–28)
TNF-α (pg/mL)
25.0 (20.5–30.2)
34.2 (31.6–45.6)
42.0 (37.6–47.2)
58.7 (48.7–64.0)
hs-CRP (mg/L)
1.05 (0.58–2.5)
3.8 (3.1–7.0)
5.2 (4.9–7.7)
6.3 (5.8–11.0)
hs-TnT (ng/L)
—
5.2 (3.0–6.6)
5.9 (3.0–8.4)
8.6+ (3.0–18.5)
AOPPs-albumin (μmol/g)
1.7 (0.8–2.7)
2.8 (1.3–4.4)
3.2 (1.9–4.5)
4.1 (2.3–5.2)
Continuous variables are expressed as median (interquartile range). Significance between groups: ; versus healthy controls; +; ++versus Child-Pugh A. AOPPs: advanced oxidation protein products; hs-TnT: high-sensitive troponin T; INR: international normalized ratio; MELD: model of end-stage liver disease.
