Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis

Table 2

Analysis of survival by lipid profiles in ICU patients adjusted for age, sex, body mass index, and Sequential Organ Failure Assessment score.

Variables		Median (IQR)	Hazard ratio	95% CI	value
Day 0	Cholesterol	95.0 [65.5, 132.0]	1.003	0.995 to 1.010	0.469
	TG	92.0 [62.0, 137.3]	0.991	0.984 to 0.998	0.015
	HDL	21.0 [11.3, 28.8]	1.018	0.991 to 1.045	0.192
	LDL	40.0 [26.3, 68.3]	1.008	0.995 to 1.021	0.246
	FFA	457.0 [256.3, 692.0]	0.999	0.998 to 1.000	0.124
	Apo A-I	6.5 [2.8, 19.0]	1.000	0.945 to 1.025	0.986
Day 1	Cholesterol	88.0 [63.8, 116.3]	1.006	0.997 to 1.015	0.210
	TG	93.0 [62.8, 145.3]	0.988	0.980 to 0.995	0.002
	HDL	19.0 [10.0, 26.0]	1.024	0.996 to 1.052	0.091
	LDL	37.0 [22.0, 64.0]	1.015	1.000 to 1.030	0.047
	FFA	313.5 [166.0, 525.0]	0.999	0.997 to 1.000	0.146
	Apo A-I	5.7 [2.7, 17.7]	1.004	0.978 to 1.030	0.780
Day 3	Cholesterol	88.0 [58.0, 113.5]	1.003	0.991 to 1.016	0.606
	TG	90.0 [65.0, 130.0]	0.998	0.991 to 1.004	0.470
	HDL	14.0 [8.0, 26.0]	1.034	0992 to 1.078	0.116
	LDL	42.0 [23.8, 61.3]	1.013	0.994 to 1.032	0.189
	FFA	301.0 [145.0, 394.5]	1.000	0.998 to 1.003	0.649
	Apo A-I	5.3 [2.8, 17.6]	1.006	0.972 to 1.041	0.720
Day 7	Cholesterol	94.0 [76.0, 121.5]	0.994	0.981 to 1.008	0.393
	TG	101.0 [73.0, 136.0]	0.999	0.987 to 1.009	0.728
	HDL	19.5 [13.8, 26.0]	1.032	0.975 to 1.092	0.274
	LDL	47.5 [30.5, 71.5]	0.986	0.968 to 1.005	0.156
	FFA	301.0 [167.5, 403.0]	1.002	1.000 to 1.003	0.112
	Apo A-I	8.5 [2.9, 18.7]	0.980	0.934 to 1.027	0.392

ICU, intensive care unit; TG, triglyceride; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FFA, free fatty acid; Apo A-I, apolipoprotein A-I; IQR, interquartile range.