Cyclic Tensile Strain Induces Tenogenic Differentiation of Tendon-Derived Stem Cells in Bioreactor Culture

Figure 5

Ingenuity interactome analysis of the effect of cyclic tensile strain-affected gene expression was performed using the Ingenuity software. The gene products in network were displayed as nodes, and the biological relationships between the nodes were displayed as lines. Different shapes represented different functional classes of gene products. The color of each node indicates the degree of upregulation (red) or downregulation (green) of the respective gene transcript. Network 1: the COPS5 and NPM1 network connected with several important canonical pathways, which shows the connection of this network to DNA replication.