Cyclic Tensile Strain Induces Tenogenic Differentiation of Tendon-Derived Stem Cells in Bioreactor Culture

Table 3

KEGG signaling pathways associated with transcriptome expression differences between the cyclic tensile strain and no treatment.

Term	Count	%	value	Genes
rno03030: DNA replication	21	2.341137124	1.00E − 17	LIG1, POLE, MCM2, POLA2, MCM3, LOC317415, RNASEH2B, MCM4, MCM5, MCM6, RPA3, PRIM1, RFC5, RPA2, MCM7, RFC4, RFC2, POLE3, POLD2, PRIM2, PCNA, FEN1
rno04110: cell cycle	34	3.790412486	9.83E − 16	E2F1, E2F5, DBF4, TTK, CHEK1, CHEK2, CCNE2, CCNE1, CDKN2A, MCM7, BUB1, MYC, CCNA2, BUB3, CDC6, RBL1, ESPL1, CDC20, CDK6, MCM2, CDC25C, MCM3, LOC317415, MCM4, MCM5, ATM, SMC3, MCM6, CCNB1, CCND1, MAD2L1, CCNB2, PLK1, PCNA, BUB1B
rno03050: proteasome	18	2.006688963	1.27E − 10	PSMB10, PSMB4, PSMB7, PSMC6, PSMD14, PSMB6, PSMC5, PSMA6, PSMC4, PSMB1, PSMA5, PSME2, PSMA4, PSMB3, PSMC1, PSMA3, POMP, PSMD6
rno00240: pyrimidine metabolism	20	2.229654404	1.06E − 07	POLR3G, POLR1E, CTPS, POLE, POLR1A, POLR1C, CAD, POLA2, POLR3D, PRIM1, TYMS, UMPS, NME2, POLE3, NT5C3, RRM2, POLD2, PRIM2, UCK2, DUT
rno03430: mismatch repair	10	1.114827202	5.35E − 07	EXO1, RFC5, RPA2, RFC4, RFC2, MSH2, LIG1, POLD2, PCNA, RPA3
rno04115: p53 signaling pathway	15	1.672240803	3.77E − 06	BID, STEAP3, CDK6, CHEK1, CHEK2, ATM, GTSE1, CCNE2, CCNB1, CCNE1, CCND1, CASP3, CDKN2A, CCNB2, RRM2
rno03420: nucleotide excision repair	11	1.226309922	4.08E − 05	RFC5, RPA2, RFC4, POLE3, RFC2, LIG1, POLE, POLD2, PCNA, ERCC1, RPA3
rno00230: purine metabolism	21	2.341137124	8.38E − 05	POLR3G, POLR1E, NUDT5, POLE, POLR1A, POLR1C, POLA2, PPAT, GART, POLR3D, PRIM1, NME2, POLE3, ATIC, NT5C3, RRM2, ADK, POLD2, PRIM2, PRPS2, PRPS1
rno00670: one carbon pool by folate	6	0.668896321	6.33E − 04	MTHFD1, MTHFS, TYMS, DHFR, ATIC, GART
rno03440: homologous recombination	7	0.780379041	0.001556012	RPA2, NBN, POLD2, BRCA2, RAD54L, RPA3, RAD51
rno03410: base excision repair	8	0.891861761	0.002577441	POLE3, NEIL3, LIG1, POLE, POLD2, PCNA, APEX1, FEN1
rno04114: oocyte meiosis	14	1.560758082	0.003751587	PPP2R1B, SGOL1, ESPL1, CDC20, CDC25C, SMC3, CCNB1, CCNE2, CCNE1, MAD2L1, CCNB2, PLK1, BUB1, FBXO5
rno00270: cysteine and methionine metabolism	7	0.780379041	0.00748193	GOT1, AHCY, DNMT1, AHCYL2, AMD1, APIP, SMS
rno05322: systemic lupus erythematosus	11	1.226309922	0.014926373	HIST1H2BA, HIST1H2BB, HIST1H2BH, SSB, LOC682330, LOC680498, HIST1H2BM, HIST1H4B, HIST2H2AC, HIST1H2AI, HIST3H2A, H2AFX, HIST1H2AO
rno03040: spliceosome	13	1.449275362	0.018817601	PRPF31, PPIL1, EFTUD2, MAGOH, SNRPB2, CWC15, SNRPD2, SF3B2, PRPF19, PLRG1, THOC4, LSM3, SNRPF
rno00480: glutathione metabolism	7	0.780379041	0.039033496	LAP3, ODC1, GSTA2, GSTA4, RRM2, SMS, GCLM
rno03020: RNA polymerase	5	0.557413601	0.039888482	POLR3G, POLR1E, POLR1A, POLR1C, POLR3D
rno04512: ECM-receptor interaction	16	2.285714286	7.51E − 07	IBSP, COL4A2, ITGA1, ITGA11, LAMA2, LAMA4, LAMB2, LAMA5, ITGB8, ITGA7, TNN, AGRN, LAMC1, COL11A1, THBS2, THBS4
rno04510: focal adhesion	24	3.428571429	3.96E − 06	IBSP, COL4A2, VAV3, ITGA11, ITGA1, IGF1, HGF, MYL9, LAMA2, LAMA4, LAMB2, LAMA5, ITGB8, ITGA7, PDGFRA, PDGFRB, TNN, LAMC1, EGF, COL11A1, FIGF, THBS2, SHC4, THBS4
rno05414: dilated cardiomyopathy	11	1.571428571	0.003630871	LAMA2, ADCY4, ITGB8, ITGA7, ADCY6, ITGA11, ITGA1, IGF1, CACNB3, CACNA1C, SGCB
rno04270: vascular smooth muscle contraction	12	1.714285714	0.00645965	RAMP3, ADCY4, AGTR1A, ADORA2A, PPP1R12B, ADCY6, AVPR1A, NPR2, PRKG1, CACNA1C, PRKCE, MYL9
rno00230: purine metabolism	14	2	0.010450898	ADCY4, ENPP3, ADCY6, PDE10A, PDE3A, NPR2, PDE4D, AMPD3, POLD4, PDE7B, PDE4B, ENTPD4, ENTPD1, ENTPD2
rno05410: hypertrophic cardiomyopathy (HCM)	9	1.285714286	0.02148213	LAMA2, ITGB8, ITGA7, ITGA11, ITGA1, IGF1, CACNB3, CACNA1C, SGCB
rno05412: arrhythmogenic right ventricular cardiomyopathy (ARVC)	8	1.142857143	0.031599478	LAMA2, ITGB8, ITGA7, ITGA11, ITGA1, CACNB3, CACNA1C, SGCB
rno04614: renin-angiotensin system	4	0.571428571	0.046740741	AGTR1A, MME, ANPEP, ENPEP