Table 1: Overview of BAFF receptors.

GeneFormsLigandsAffinity to BAFF ()Tissue expressionFunctionClinical relevance

BAFF-R
(BAFF-receptor, TNFRSF13C, BLyS, BR3, CD268) [13]
22q13.2
3 exons [13]
Membrane bound, soluble (produced by decidual cells) [8, 14]BAFF [8]16 nmol·l−1 [8]B-, T-cells [15, 16]
mature and immature adipose tissue [17]
B-cell proliferation [18],
T-cell proliferation [16]
BAFF-R is constitutively saturated in autoimmune and lymphoproliferative diseases [15, 19, 20]

TACI
(transmembrane activator and calcium signal-modulating cyclophilin ligand, TNFRSF13B, CD267) [21]
17p11.2
5 exons [21]
Membrane bound [8]BAFF, APRIL [8]146 nmol·l−1 [22]B-, T-cells
immature adipose tissue [17]
T-cell activation [23] and humoral immunity response modulation [24, 25]Mutations may result in common variable immunodeficiency [26, 27]

BCMA
(B-cell maturation antigen, TNFRSF17) [28]
16p13.1
3 exons [28]
Membrane bound [8]APRIL (BAFF) [8]1600 nmol·l−1 [8]B-cells
immature [17]
Long-term plasma cell survival, B-cell antigen presentation [29]Protection of multiple myeloma cells from apoptosis [30, 31]