Computational Analysis of the Binding Specificities of PH Domains

Figure 5

Ligand binding of the domains. The phosphatidyl inositol-binding residues are indicated by open triangles (). The insertions in the aligned sequences were deleted. The SASA for the PH domains and their complexes with inositol phosphates are marked with S0 and S1, respectively. H, F, E, and I represent hydropathy, flexibility, electronic charge concentration, and isotropic surface area, respectively.

(a)

(b)

(c)

(d)

(e)